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  1. Article

    Open Access

    COVID-19 coagulopathy: is it disseminated intravascular coagulation?

    One of the significant complications of severe COVID-19 infections is a coagulopathy that seems to be related to the occurrence of venous and arterial thromboembolic disease. The coagulation changes mimic but ...

    Marcel Levi, Toshiaki Iba in Internal and Emergency Medicine (2021)

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  2. No Access

    Article

    Disseminated intravascular coagulation

    Disseminated intravascular coagulation (DIC) is an acquired syndrome characterized by widespread intravascular activation of coagulation that can be caused by infectious insults (such as sepsis) and non-infect...

    Satoshi Gando, Marcel Levi, Cheng-Hock Toh in Nature Reviews Disease Primers (2016)

  3. No Access

    Article

    Hemostatic abnormalities in critically ill patients

    Hemostatic abnormalities frequently occur in critically ill patients and may vary from prolonged global clotting tests or isolated thrombocytopenia, to composite defects, such as consumption coagulopathies. Th...

    Marcel Levi, Suthesh Sivapalaratnam in Internal and Emergency Medicine (2015)

  4. No Access

    Article

    Disseminated intravascular coagulation: a review for the internist

    Disseminated intravascular coagulation (DIC) is a syndrome characterized by systemic intravascular activation of coagulation, leading to widespread deposition of fibrin in the circulation. Recent knowledge on ...

    Marcel Levi, Tom van der Poll in Internal and Emergency Medicine (2013)

  5. Article

    Open Access

    Early intravenous unfractionated heparin and outcome in acute lung injury and acute respiratory distress syndrome – a retrospective propensity matched cohort study

    Acute lung injury (ALI) is characterized by a pro-coagulant state. Heparin is an anticoagulant with anti-inflammatory properties. Unfractionated heparin has been found to be protective in experimental models o...

    Jorrit J Hofstra, Alexander P J Vlaar, David J Prins, Gavin Koh… in BMC Pulmonary Medicine (2012)

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  6. Article

    Open Access

    Systemic versus localized coagulation activation contributing to organ failure in critically ill patients

    In the pathogenesis of sepsis, inflammation and coagulation play a pivotal role. Increasing evidence points to an extensive cross-talk between these two systems, whereby inflammation not only leads to activati...

    Marcel Levi, Tom van der Poll, Marcus Schultz in Seminars in Immunopathology (2012)

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  7. No Access

    Article

    Emergency reversal of antithrombotic treatment

    The most important adverse effect of antithrombotic treatment is the occurrence of bleeding. In case of serious or even life-threatening bleeding in a patient who uses anticoagulant agents or when a patient on...

    Marcel Levi in Internal and Emergency Medicine (2009)

  8. No Access

    Article

    Prevention and Treatment of Bleeding by Pro-hemostatic Treatment Strategies

    Pro-hemostatic therapy may achieve an improvement of hemostasis, by amelioration of primary hemostasis, stimulation of fibrin formation or inhibition of fibrinolysis. Pro-hemostatic interventions appear to be ...

    Marcel Levi, Roel Vink, Evert de Jonge in Wiener Medizinische Wochenschrift (2003)

  9. No Access

    Article

    Drotrecogin Alfa (Activated)

    Marcel Levi in Drugs (2002)

  10. No Access

    Article

    Current Drug Treatment Strategies for Disseminated Intravascular Coagulation

    Disseminated intravascular coagulation (DIC) can be caused by a variety of diseases. Experimental models of DIC have provided substantial insight into the pathogenesis of this disorder, which may ultimately re...

    Dr Evert de Jonge, Marcel Levi, Christiaan P. Stoutenbeek… in Drugs (1998)

  11. No Access

    Article

    Acute hepatitis in a patient using a Chinese herbal tea ‐ a case report.

    A case is presented of reversible acute hepatitis in a patient using a Chinese herbal tea. Upon identification of the tea mixture Aristolochia species, including A. debilis, which contains the highly toxic ari...

    Marcel Levi, Henk‐Jan Guchelaar, Herman J. Woerdenbag… in Pharmacy World and Science (1998)

  12. No Access

    Article

    Inhibition of the release of soluble tumor necrosis factor receptors in experimental endotoxemia by an anti-tumor necrosis factor-α antibody

    The role of tumor necrosis factor-α in the shedding of soluble tumor necrosis factor receptors in endotoxemia was investigated. The appearance of the soluble tumor necrosis factor receptors was assessed in four h...

    Jaap Jansen, Tom van der Poll, Marcel Levi, Hugo ten Cate… in Journal of Clinical Immunology (1995)