30 Result(s)

Article

Nevertheless, the importance of coagulation abnormalities should be emphasized in international sepsis guidelines

It is generally accepted that a coagulation/fibrinolysis disorder is involved in the pathogenesis of sepsis, and the association of disseminated intravascular coagulation (DIC) and poor outcomes have been repo...

Toshiaki Iba, Osamu Nishida, Jerrold H. Levy, Marcel Levi in Journal of Intensive Care (2022)

Article

The unique characteristics of COVID-19 coagulopathy

Thrombotic complications and coagulopathy frequently occur in COVID-19. However, the characteristics of COVID-19-associated coagulopathy (CAC) are distinct from those seen with bacterial sepsis-induced coagulo...

Toshiaki Iba, Jerrold H. Levy, Jean Marie Connors, Theodore E. Warkentin… in Critical Care (2020)

Article

What do sepsis-induced coagulation test result abnormalities mean to intensivists?

Marcel Levi, Marcus J. Schultz in Intensive Care Medicine (2017)

Article

Management of bleeding in patients treated with direct oral anticoagulants

Recently, a new generation of direct-acting oral anticoagulants (DOACs) with a greater specificity towards activated coagulation factors was introduced based on encouraging results for efficacy and safety in c...

Marcel Levi in Critical Care (2016)

Article

Another step in improving the diagnosis of disseminated intravascular coagulation in sepsis

The diagnosis of disseminated intravascular coagulation (DIC) based on composite scoring systems using routinely available coagulation tests has been greatly facilitated. Such scoring instruments not only adeq...

Marcel Levi in Critical Care (2013)

Article

Protease-activated receptor-1 impairs host defense in murine pneumococcal pneumonia: a controlled laboratory study

Streptococcus pneumoniae is the most common causative pathogen in community-acquired pneumonia. Protease-activated receptor-1 (PAR-1) is expressed by multiple cell types present in the lungs and can be activated ...

Marcel Schouten, Cornelis van't Veer, Joris JTH Roelofs, Marcel Levi… in Critical Care (2012)

Article

Early intravenous unfractionated heparin and outcome in acute lung injury and acute respiratory distress syndrome – a retrospective propensity matched cohort study

Acute lung injury (ALI) is characterized by a pro-coagulant state. Heparin is an anticoagulant with anti-inflammatory properties. Unfractionated heparin has been found to be protective in experimental models o...

Jorrit J Hofstra, Alexander P J Vlaar, David J Prins, Gavin Koh… in BMC Pulmonary Medicine (2012)

Article

Nebulized anticoagulants for acute lung injury - a systematic review of preclinical and clinical investigations

Data from interventional trials of systemic anticoagulation for sepsis inconsistently suggest beneficial effects in case of acute lung injury (ALI). Severe systemic bleeding due to anticoagulation may have off...

Pieter R Tuinman, Barry Dixon, Marcel Levi, Nicole P Juffermans… in Critical Care (2012)

Article

Blood transfusion during cardiac surgery is associated with inflammation and coagulation in the lung: a case control study

Blood transfusion is associated with increased morbidity and mortality in cardiac surgery patients, but cause-and-effect relations remain unknown. We hypothesized that blood transfusion is associated with chan...

Pieter R Tuinman, Alexander P Vlaar, Alexander D Cornet, Jorrit J Hofstra… in Critical Care (2011)

Article

Treatment with recombinant human activated protein C: one size does not fit all

Protein C plays an important role in the coagulopathy associated with sepsis and probably also in the pathogenesis of sepsis-induced organ dysfunction. Plasma levels of protein C strongly correlate with clinic...

Marcel Levi in Critical Care (2011)

Article

Impact of the factor V Leiden mutation on the outcome of pneumococcal pneumonia: a controlled laboratory study

Streptococcus (S.) pneumoniae is the most common cause of community-acquired pneumonia. The factor V Leiden (FVL) mutation results in resistance of activated FV to inactivation by activated protein C and thereby ...

Marcel Schouten, Cornelis van't Veer, Joris JTH Roelofs, Marcel Levi… in Critical Care (2010)

Article

Adequate thromboprophylaxis in critically ill patients

Venous thromboembolism is a relatively frequently occurring complication in critically ill patients admitted to the ICU despite prophylactic treatment with subcutaneous low molecular weight heparin. Several st...

Marcel Levi in Critical Care (2010)

Article

Nebulized antithrombin limits bacterial outgrowth and lung injury in Streptococcus pneumoniae pneumonia in rats

Disturbed alveolar fibrin turnover is a cardinal feature of severe pneumonia. Clinical studies suggest that natural inhibitors of coagulation exert lung-protective effects via anticoagulant and possibly also a...

Jorrit J Hofstra, Alexander D Cornet, Bart F de Rooy, Alexander P Vlaar… in Critical Care (2009)

Article

Comprehensive safety analysis of concomitant drotrecogin alfa (activated) and prophylactic heparin use in patients with severe sepsis

Mitchell Levy, Marcel Levi, Mark D. Williams, Massimo Antonelli… in Intensive Care Medicine (2009)

Article

Comprehensive safety analysis of concomitant drotrecogin alfa (activated) and prophylactic heparin use in patients with severe sepsis

The safety of using heparin concomitantly with drotrecogin alfa (activated) {DrotAA} was explored in the XPRESS study. No heparin effect on mortality was observed. Safety results from that study are explored i...

Mitchell Levy, Marcel Levi, Mark D. Williams, Massimo Antonelli… in Intensive Care Medicine (2009)

Article

The inflammation–coagulation axis as an important intermediate pathway in acute lung injury

Markers of inflammation, coagulation, and fibrinolysis predict an adverse outcome in patients with sepsis. These markers also seem predictive of an adverse outcome in patients with localized infection and infl...

Marcel Levi, Marcus Schultz in Critical Care (2008)

Article

Recombinant human activated protein C: current insights into its mechanism of action

Impairment of the protein C pathway plays a central role in the pathogenesis of sepsis. Administration of recombinant human activated protein C (rhAPC) may correct the dysregulated anticoagulant mechanism and ...

Marcel Levi, Tom van der Poll in Critical Care (2007)