59 Result(s)

Article

Nevertheless, the importance of coagulation abnormalities should be emphasized in international sepsis guidelines

It is generally accepted that a coagulation/fibrinolysis disorder is involved in the pathogenesis of sepsis, and the association of disseminated intravascular coagulation (DIC) and poor outcomes have been repo...

Toshiaki Iba, Osamu Nishida, Jerrold H. Levy, Marcel Levi in Journal of Intensive Care (2022)

Article

Endothelial dysfunction and immunothrombosis as key pathogenic mechanisms in COVID-19

Coronavirus disease 2019 (COVID-19) is a clinical syndrome caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Patients with severe disease show hyperactivation of the immune...

Aldo Bonaventura, Alessandra Vecchié, Lorenzo Dagna… in Nature Reviews Immunology (2021)

Article

COVID-19 coagulopathy: is it disseminated intravascular coagulation?

One of the significant complications of severe COVID-19 infections is a coagulopathy that seems to be related to the occurrence of venous and arterial thromboembolic disease. The coagulation changes mimic but ...

Marcel Levi, Toshiaki Iba in Internal and Emergency Medicine (2021)

Article

Author Correction: Scalable and robust SARS-CoV-2 testing in an academic center

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Jim Aitken, Karen Ambrose, Sam Barrell, Rupert Beale… in Nature Biotechnology (2020)

Article

Scalable and robust SARS-CoV-2 testing in an academic center

Jim Aitken, Karen Ambrose, Sam Barrell, Rupert Beale… in Nature Biotechnology (2020)

Article

The unique characteristics of COVID-19 coagulopathy

Thrombotic complications and coagulopathy frequently occur in COVID-19. However, the characteristics of COVID-19-associated coagulopathy (CAC) are distinct from those seen with bacterial sepsis-induced coagulo...

Toshiaki Iba, Jerrold H. Levy, Jean Marie Connors, Theodore E. Warkentin… in Critical Care (2020)

Article

Strengths and weaknesses of the acute care systems in the United Kingdom and the Netherlands: what can we learn from each other?

The demand on Emergency Departments and acute medical services is increasing internationally, creating pressure on health systems and negatively influencing the quality of delivered care. Visible consequences ...

Marjolein N. T. Kremers, Prabath W. B. Nanayakkara, Marcel Levi… in BMC Emergency Medicine (2019)

Article

What do sepsis-induced coagulation test result abnormalities mean to intensivists?

Marcel Levi, Marcus J. Schultz in Intensive Care Medicine (2017)

Article

Management of bleeding in patients treated with direct oral anticoagulants

Recently, a new generation of direct-acting oral anticoagulants (DOACs) with a greater specificity towards activated coagulation factors was introduced based on encouraging results for efficacy and safety in c...

Marcel Levi in Critical Care (2016)

Article

Another step in improving the diagnosis of disseminated intravascular coagulation in sepsis

The diagnosis of disseminated intravascular coagulation (DIC) based on composite scoring systems using routinely available coagulation tests has been greatly facilitated. Such scoring instruments not only adeq...

Marcel Levi in Critical Care (2013)

Article

Protease-activated receptor-1 impairs host defense in murine pneumococcal pneumonia: a controlled laboratory study

Streptococcus pneumoniae is the most common causative pathogen in community-acquired pneumonia. Protease-activated receptor-1 (PAR-1) is expressed by multiple cell types present in the lungs and can be activated ...

Marcel Schouten, Cornelis van't Veer, Joris JTH Roelofs, Marcel Levi… in Critical Care (2012)

Article

Early intravenous unfractionated heparin and outcome in acute lung injury and acute respiratory distress syndrome – a retrospective propensity matched cohort study

Acute lung injury (ALI) is characterized by a pro-coagulant state. Heparin is an anticoagulant with anti-inflammatory properties. Unfractionated heparin has been found to be protective in experimental models o...

Jorrit J Hofstra, Alexander P J Vlaar, David J Prins, Gavin Koh… in BMC Pulmonary Medicine (2012)