Skip to main content

and
  1. No Access

    Article

    Inflammation, coagulation, and cellular injury in heat-induced shock

    The number of heatstroke victims hit record numbers in 2022 as global warming continues. In heat-induced injuries, circulatory shock is the most severe and deadly complication. This review aims to examine the ...

    Toshiaki Iba, Julie Helms, Marcel Levi, Jerrold H. Levy in Inflammation Research (2023)

  2. Article

    Endothelial dysfunction and immunothrombosis as key pathogenic mechanisms in COVID-19

    Coronavirus disease 2019 (COVID-19) is a clinical syndrome caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Patients with severe disease show hyperactivation of the immune...

    Aldo Bonaventura, Alessandra Vecchié, Lorenzo Dagna in Nature Reviews Immunology (2021)

  3. Article

    Open Access

    Systemic versus localized coagulation activation contributing to organ failure in critically ill patients

    In the pathogenesis of sepsis, inflammation and coagulation play a pivotal role. Increasing evidence points to an extensive cross-talk between these two systems, whereby inflammation not only leads to activati...

    Marcel Levi, Tom van der Poll, Marcus Schultz in Seminars in Immunopathology (2012)

  4. Article

    Open Access

    Acute Stress Elicited by Bungee Jum** Suppresses Human Innate Immunity

    Although a relation between diminished human immunity and stress is well recognized both within the general public and the scientific literature, the molecular mechanisms by which stress alters immunity remain...

    David J. van Westerloo, Goda Choi, Ester C. Löwenberg, Jasper Truijen in Molecular Medicine (2011)

  5. No Access

    Article

    Fibrinogen-coated albumin microcapsules reduce bleeding in severely thrombocytopenic rabbits

    Severe thrombocytopenia frequently occurs in patients receiving chemotherapy and in patients with autoimmune disorders. Thrombocytopenia is associated with bleeding, which may be serious and life threatening1,2,3

    Marcel Levi, Philip W. Friederich, Sarah Middleton, Philip G. de Groot in Nature Medicine (1999)

  6. No Access

    Article

    Inhibition of the release of soluble tumor necrosis factor receptors in experimental endotoxemia by an anti-tumor necrosis factor-α antibody

    The role of tumor necrosis factor-α in the shedding of soluble tumor necrosis factor receptors in endotoxemia was investigated. The appearance of the soluble tumor necrosis factor receptors was assessed in four h...

    Jaap Jansen, Tom van der Poll, Marcel Levi, Hugo ten Cate in Journal of Clinical Immunology (1995)