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Article
Inflammation, coagulation, and cellular injury in heat-induced shock
The number of heatstroke victims hit record numbers in 2022 as global warming continues. In heat-induced injuries, circulatory shock is the most severe and deadly complication. This review aims to examine the ...
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Article
Endothelial dysfunction and immunothrombosis as key pathogenic mechanisms in COVID-19
Coronavirus disease 2019 (COVID-19) is a clinical syndrome caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Patients with severe disease show hyperactivation of the immune...
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Article
Open AccessSystemic versus localized coagulation activation contributing to organ failure in critically ill patients
In the pathogenesis of sepsis, inflammation and coagulation play a pivotal role. Increasing evidence points to an extensive cross-talk between these two systems, whereby inflammation not only leads to activati...
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Article
Open AccessAcute Stress Elicited by Bungee Jum** Suppresses Human Innate Immunity
Although a relation between diminished human immunity and stress is well recognized both within the general public and the scientific literature, the molecular mechanisms by which stress alters immunity remain...
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Article
Fibrinogen-coated albumin microcapsules reduce bleeding in severely thrombocytopenic rabbits
Severe thrombocytopenia frequently occurs in patients receiving chemotherapy and in patients with autoimmune disorders. Thrombocytopenia is associated with bleeding, which may be serious and life threatening1,2,3
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Article
Inhibition of the release of soluble tumor necrosis factor receptors in experimental endotoxemia by an anti-tumor necrosis factor-α antibody
The role of tumor necrosis factor-α in the shedding of soluble tumor necrosis factor receptors in endotoxemia was investigated. The appearance of the soluble tumor necrosis factor receptors was assessed in four h...