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  1. Article

    Open Access

    RTEL1 influences the abundance and localization of TERRA RNA

    Telomere repeat containing RNAs (TERRAs) are a family of long non-coding RNAs transcribed from the subtelomeric regions of eukaryotic chromosomes. TERRA transcripts can form R-loops at chromosome ends; however...

    Fiorella Ghisays, Aitor Garzia, Hexiao Wang… in Nature Communications (2021)

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    Article

    Eukaryotic Rad50 functions as a rod-shaped dimer

    Structural, biochemical and in vivo analyses reveal that Rad50 zinc-hook and coiled-coil domains form a novel dimerization interface essential for Mre11-complex function in DNA damage response and repair.

    Young Bong Park, Marcel Hohl, Michał Padjasek… in Nature Structural & Molecular Biology (2017)

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    Article

    The Rad50 coiled-coil domain is indispensable for Mre11 complex functions

    Rad50 is part of the Mre11 complex, which plays a central role in DNA damage response and repair. Rad50 has a long coiled-coil region that links its globular DNA-binding domain and hook. Now the role of this r...

    Marcel Hohl, Youngho Kwon, Sandra Muñoz Galván… in Nature Structural & Molecular Biology (2011)

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    Article

    The Rad50 hook domain is a critical determinant of Mre11 complex functions

    The Mre11 complex (in Saccharomyces cerevisiae: Mre11, Rad50 and Xrs2) influences multiple facets of chromosome break metabolism. A conserved feature of the Mre11 complex is a zinc-coordinating motif in Rad50 cal...

    Jed J W Wiltzius, Marcel Hohl, James C Fleming… in Nature Structural & Molecular Biology (2005)