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Article
Open AccessGhost admixture in eastern gorillas
Archaic admixture has had a substantial impact on human evolution with multiple events across different clades, including from extinct hominins such as Neanderthals and Denisovans into modern humans. In great ...
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Article
Open AccessOrigin and diffusion of human Y chromosome haplogroup J1-M267
Human Y chromosome haplogroup J1-M267 is a common male lineage in West Asia. One high-frequency region—encompassing the Arabian Peninsula, southern Mesopotamia, and the southern Levant—resides ~ 2000 km away f...
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Article
Open AccessEnrichment of low-frequency functional variants revealed by whole-genome sequencing of multiple isolated European populations
The genetic features of isolated populations can boost power in complex-trait association studies, and an in-depth understanding of how their genetic variation has been shaped by their demographic history can ...
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Article
Open AccessMap** Post-Glacial expansions: The Peopling of Southwest Asia
Archaeological, palaeontological and geological evidence shows that post-glacial warming released human populations from their various climate-bound refugia. Yet specific connections between these refugia and ...
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Article
Open AccessAncient DNA and the rewriting of human history: be sparing with Occam’s razor
Ancient DNA research is revealing a human history far more complex than that inferred from parsimonious models based on modern DNA. Here, we review some of the key events in the peopling of the world in the li...
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Impact of inflammation, gene variants, and cigarette smoking on coronary artery disease risk
The role of inflammation in coronary artery disease (CAD) pathogenesis is well recognized. Moreover, smoking inhalation increases the activity of inflammatory mediators through an increase in leukotriene synth...
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Circulating lipid levels and risk of coronary artery disease in a large group of patients undergoing coronary angiography
A main underlying pathology of coronary artery disease is the deposition of cholesterol in the arteries supplying blood to the heart that leads to stenosis and myocardial infarction. We tested if dyslipidemia ...
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Article
Open AccessT2DM GWAS in the Lebanese population confirms the role of TCF7L2 and CDKAL1 in disease susceptibility
Genome-wide association studies (GWAS) of multiple populations with distinctive genetic and lifestyle backgrounds are crucial to the understanding of Type 2 Diabetes Mellitus (T2DM) pathophysiology. We report ...
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Open AccessDifferent waves and directions of Neolithic migrations in the Armenian Highland
The peopling of Europe and the nature of the Neolithic agricultural migration as a primary issue in the modern human colonization of the globe is still widely debated. At present, much uncertainty is associate...
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Article
Open AccessMultivariate epidemiologic analysis of type 2 diabetes mellitus risks in the Lebanese population
The burden of diabetes in Lebanon requires well-targeted interventions for screening type 2 diabetes mellitus (T2DM) and prediabetes and prevention of risk factors. Newly recruited 998 Lebanese individuals, in...
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Article
Recombination networks as genetic markers in a human variation study of the Old World
We have analyzed human genetic diversity in 33 Old World populations including 23 populations obtained through Genographic Project studies. A set of 1,536 SNPs in five X chromosome regions were genotyped in 1,...
