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Article
Open AccessSeeding the meiotic DNA break machinery and initiating recombination on chromosome axes
Programmed DNA double-strand break (DSB) formation is a crucial feature of meiosis in most organisms. DSBs initiate recombination-mediated linking of homologous chromosomes, which enables correct chromosome se...
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Article
Open AccessWie man ein Glashaus baut: die außergewöhnlichen Proteine der Kieselalgen
The biological formation of inorganic structures (biominerals) is a very widespread biological phenomenon. The silica-based cell walls of diatoms are among the most fascinating biominerals displaying complex a...
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Article
Open AccessDickkopf1 fuels inflammatory cytokine responses
Many human diseases, including cancer, share an inflammatory component but the molecular underpinnings remain incompletely understood. We report that physiological and pathological Dickkopf1 (DKK1) activity fu...
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Article
Open AccessProteomic consequences of TDA1 deficiency in Saccharomyces cerevisiae: Protein kinase Tda1 is essential for Hxk1 and Hxk2 serine 15 phosphorylation
Hexokinase 2 (Hxk2) of Saccharomyces cerevisiae is a dual function hexokinase, acting as a glycolytic enzyme and being involved in the transcriptional regulation of glucose-repressible genes. Relief from glucose ...
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Article
Open AccessAuthor Correction: Gap junction protein Connexin-43 is a direct transcriptional regulator of N-cadherin in vivo
The original version of this Article contained an error in the spelling of the author Alexandra Schambony, which was incorrectly given as Alexandra Schambon. This has now been corrected in both the PDF and HTM...
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Article
Open AccessGap junction protein Connexin-43 is a direct transcriptional regulator of N-cadherin in vivo
Connexins are the primary components of gap junctions, providing direct links between cells under many physiological processes. Here, we demonstrate that in addition to this canonical role, Connexins act as tr...
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Article
RanGTP mediates nuclear pore complex assembly
In metazoa, the nuclear envelope breaks down and reforms during each cell cycle. Nuclear pore complexes (NPCs), which serve as channels for transport between the nucleus and cytoplasm1, assemble into the reformin...
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Article
Noise filtering techniques for electrospray quadrupole time of flight mass spectra
The sensitivity of protein identification by peptide sequencing using a nanoelectrospray ion source is limited by our ability to identify peptide ions in the mass spectrum. Their intensity must be higher than ...
