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Open AccessAuthor Correction: Probabilistic embedding, clustering, and alignment for integrating spatial transcriptomics data with PRECAST
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Open AccessBayesian risk prediction model for colorectal cancer mortality through integration of clinicopathologic and genomic data
Routine tumor-node-metastasis (TNM) staging of colorectal cancer is imperfect in predicting survival due to tumor pathobiological heterogeneity and imprecise assessment of tumor spread. We leveraged Bayesian a...
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Open AccessSpatially resolved multimarker evaluation of CD274 (PD-L1)/PDCD1 (PD-1) immune checkpoint expression and macrophage polarisation in colorectal cancer
The CD274 (PD-L1)/PDCD1 (PD-1) immune checkpoint interaction may promote cancer progression, but the expression patterns and prognostic significance of PD-L1 and PD-1 in the colorectal cancer microenvironment ...
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Open AccessHistopathology images predict multi-omics aberrations and prognoses in colorectal cancer patients
Histopathologic assessment is indispensable for diagnosing colorectal cancer (CRC). However, manual evaluation of the diseased tissues under the microscope cannot reliably inform patient prognosis or genomic v...
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Open AccessProbabilistic embedding, clustering, and alignment for integrating spatial transcriptomics data with PRECAST
Spatially resolved transcriptomics involves a set of emerging technologies that enable the transcriptomic profiling of tissues with the physical location of expressions. Although a variety of methods have been...
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Living Reference Work Entry In depth
Spatial Technologies: A Game Changer for Studying the Tumor Microenvironment
Traditional immunohistochemistry (IHC) has long been considered the “gold standard” for tissue pathology diagnosis. However, the diagnostic and prognostic value of this technique is limited by a number of fact...
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Living Reference Work Entry In depth
The Hurdle of Precision Medicine in Cancer Immunotherapy: Personalization Now or Then?
Moving away from the generic treatment for all cancer, precision medicine provides a targeted therapy based on the different profile presented. Since the signing of Precision Medicine Initiative by the then US...
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Open AccessSmoking and colorectal cancer survival in relation to tumor LINE-1 methylation levels: a prospective cohort study
Carcinogens in cigarette smoke may cause aberrant epigenomic changes. The hypomethylation of long interspersed nucleotide element-1 (LINE-1) in colorectal carcinoma has been associated with genomic instability...
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Immune cell profiles in the tumor microenvironment of early-onset, intermediate-onset, and later-onset colorectal cancer
Despite heightened interest in early-onset colorectal cancer (CRC) diagnosed before age 50, little is known on immune cell profiles of early-onset CRC. It also remains to be studied whether CRCs diagnosed at o...
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Open AccessAn integrated analysis of lymphocytic reaction, tumour molecular characteristics and patient survival in colorectal cancer
Histological lymphocytic reaction is regarded as an independent prognostic marker in colorectal cancer. Considering the lack of adequate statistical power, adjustment for selection bias and comprehensive tumou...
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Open AccessImmunological history governs human stem cell memory CD4 heterogeneity via the Wnt signaling pathway
The diversity of the naïve T cell repertoire drives the replenishment potential and capacity of memory T cells to respond to immune challenges. Attrition of the immune system is associated with an increased pr...
