20 Result(s)
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Article
ACE I/D gene polymorphisms and polycystic ovary syndrome manifestations
Polycystic ovary syndrome (PCOS) is a common multifactorial endocrine disorder affecting women of reproductive age. ACE enzyme is involved in the physiopathology of the ovarian system, and there are inconsiste...
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Article
Association of the APOE gene variants with depression in type 2 diabetes
The risk of depression among patients with diabetes is higher than the general population. The exact mechanisms linking these two diseases are mostly unknown. Energy metabolism disorders seem to be a shared pa...
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Article
Relationship between a near Melanocortin-4 receptor gene variant and puberty timing in children is vague unlike obesity
Obesity is a complicated phenomenon which is a combination of genetic, environmental, and psychological factors. Genetic factors of obesity play an important role in individual risk. It is well known that obes...
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Article
Adenosine deaminase gene variant in diabetes and obesity
Personal medicine is a new notion for individualizing treatment in the future. Studying pathogenic markers including genetic variants would be beneficial in better diagnosis and management of complex diseases ...
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Precision Medicine Initiatives
The field of precision medicine is emergent and altering at a very growing pace. As the immense scope of initiative programs are currently underway or scheduled in the field of precision medicine in many count...
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Article
Investigation of TGF-β1 gene variant and expression in a group of Iranian women with endometriosis
Endometriosis is defined as a common gynecologic and inflammatory disease. Transforming growth factor-beta 1 (TGF-β1) gene and its protein level might play a role in the pathogenesis of endometriosis. The present...
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Article
Genetic research in Immunogenetics Group of Endocrinology and Metabolism Research Institute
Due to the high prevalence of metabolic diseases and the role of genetic factors in their susceptibility, the use of basic research in this field can be useful for screening, prevention, and treatment of metab...
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Article
Thyroid Cancer research at endocrinology and metabolism research institute (EMRI): a report of scientific activities between 2005 and 2020
Endocrinology and Metabolism Research Institute (EMRI), Tehran University of Medical Sciences, has achieved many advances in the understanding of epidemiology, pathology, and molecular biology of thyroid cance...
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Article
Inflammation related miRNAs as an important player between obesity and cancers
The growing trend in addition to their burden, prevalence, and death has made obesity and cancer two of the most concerning diseases worldwide. Obesity is an important risk factor for common types of cancers w...
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Article
Macrophage migration inhibitory factor polymorphism (rs755622) in alopecia areata: a possible role in disease prevention
Alopecia areata (AA) is an organ-specific autoimmune disease that targets the bulb of the hair follicles and results in non-scarring hair loss that can range from patchy lesions to involvement of the entire sc...
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Article
Adiponectin gene variants and abdominal obesity in an Iranian population
Waist-to-height ratio (WHtR) can be effective for the diagnosis of abdominal obesity and the risk of type 2 diabetes. The role of genetic factors in the development of obesity has been broadly recognized. Adip...
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Article
Molecular investigation of WFS1 gene exon 8 in Iranian patients with Wolfram syndrome
Most patients with Wolfram syndrome carry mutations in WFS1, while a lower percentage present a mutation in CISD2 (also known as WFS2). The aim of this study was to investigate the presence of mutations in exon 8...
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Article
Sex-specific association of RANTES gene −403 variant in Meniere’s disease
Several studies have shown the correlation between RANTES gene and inflammatory disorders; the aim of the present study was to investigate the association between RANTES promoter gene polymorphism and Meniere’...
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Article
Open AccessAssociation between vitamin D receptor gene polymorphisms (Fok1 and Bsm1) and osteoporosis: a systematic review
Osteoporosis is a health concern characterized by reduced bone mineral density (BMD) and increased risk of fragility fractures. Many studies have investigated the association between genetic variants and osteo...
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Article
Open AccessTNF-α and IFN-γ gene variation and genetic susceptibility to type 1 diabetes and its microangiopathic complications
TNF-α has accelerating role in development of type 1 diabetes. Although an immunosupressor function and leading protecting role in T1DM also has been claimed for this pro-inflammatory cytokine. Over-expression...
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Open AccessTGF-β1 and IGF-I gene variations in type 1 diabetes microangiopathic complications
Growth factors are generally believed to have a perpetuating role in the development of diabetic complications, However there is ample of evidence of a protective or therapeutic potential for some of them. IGF...
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Open AccessApolipoprotein E gene polymorphism and its effect on anthropometric measures in normoglycemic subjects and type 2 diabetes
Apolipoprotein E (apo E) plays a major role in lipid metabolism, obesity and accordingly in development of diabetes and coronary heart disease (CHD). Our main objective was to evaluate the association between ...
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Article
Open AccessEffect of adiponectin gene polymorphisms on waist circumference in patients with diabetes
Plasma levels of adiponectin which is secreted from adipose tissue are associated with various parameters of metabolic syndrome. This effect seems to be a result of interactions between genetic and environment...
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Article
Mutation screening of RET proto-oncogene in a family with medullary thyroid carcinoma, marfanoid habitus and pheochromocytoma; from clinically MEN2B to genetically MEN2A syndrome
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Article
TGF-β and IL-23 gene expression in unstimulated PBMCs of patients with diabetes
The protective effects of TGF-β have been documented in various autoimmune diseases, mostly in organ-specific autoimmunity including type 1 diabetes mellitus (T1DM). However, TGF-β also plays a role as a pro-i...
