20 Result(s)
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Mahdi Fasihi-Ramandi
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Article
Open AccessTargeted delivery of a short antimicrobial peptide (CM11) against Helicobacter pylori gastric infection using concanavalin A-coated chitosan nanoparticles
Helicobacter pylori is the cause of most cases of stomach ulcers and also causes some digestive cancers. The emergence and spread of antibiotic-resistant strains of H. pylori is one of the most important challeng...
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Interaction of antibacterial CM11 peptide with the gram-positive and gram-negative bacterial membrane models: a molecular dynamics simulations study
In the present study, a series of all-atom molecular dynamics simulations were applied to shed light on the molecular mechanism of the activity of CM11, a short cecropin–melittin hybrid peptide obtained throug...
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Molecular Docking, Anti-Biofilm & Antibacterial Activities and Therapeutic Index of mCM11 Peptide on Acinetobacter baumannii Strains
Despite the huge efforts of microbiologists, infectious diseases have yet remained one of the leading causes of death in humans, further highlighting the research priority for controlling opportunistic pathoge...
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Synthesis of novel surface-modified nanohydroxyapatite containing chitosan-functionalized graphene oxide decorated with glycidyl methacrylate (GO–CS–GMA) via ATRP for biomedical application
In the present study, a novel chitosan-functionalized graphene oxide decorated with glycidyl methacrylate (GO–CS–GMA) was synthesized and combined with nanohydroxyapatite particles (nHAp) to produce a novel hy...
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Potential diagnostic and prognostic of efferocytosis-related unwanted soluble receptors/ligands as new non-invasive biomarkers in disorders: a review
Efferocytosis is the process by which apoptotic cells are removed without inflammation to maintain tissue homeostasis, prevent unwanted inflammatory responses, and inhibit autoimmune responses. Coordination of...
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Rescuing humanity by antimicrobial peptides against colistin-resistant bacteria
It has been about a century since the discovery of the first antibiotic, and during this period, several antibiotics were produced and marketed. The production of high-potency antibiotics against infections le...
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In Silico Analysis of Inhibiting Papain-like Protease from SARS-CoV-2 by Using Plant-Derived Peptides
SARS-CoV-2 is a corona virus that has been the cause for one of the deadliest pandemics of history, started since 2019. Suppressing the activity of the critical enzymes in the SARS-CoV-2 could potentially inhi...
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d-Leucine Modified CM11 Peptide has Admissible Antibacterial Activity with Low Cytotoxic Properties Against Vero Cell Line
Discovering novel antimicrobials is highly crucial to combat drug-resistant bacteria. Antimicrobial peptides (AMPs) are one of the compounds that are being studied as suitable candidates for antibiotics. There...
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In-Silico and In-Vitro Evaluation of Antibacterial, Cytotoxic, and Apoptotic Activity and Structure of Modified CM11 Peptide
Drug-resistant infectious diseases have increased in recent years. Accordingly, plenty of researches are exploring novel approaches to overcome this problem. In this era, antimicrobial peptides have been ident...
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Conjugation of imipenem to silver nanoparticles for enhancement of its antibacterial activity against multidrug-resistant isolates of Pseudomonas aeruginosa
Due to the broad-spectrum of antibiotic resistance, herein we investigated the possibility of using imipenem-conjugated silver nanoparticles (IMP-AgNPs) against multidrug-resistant isolates of Pseudomonas aerugin...
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Article
A facile preparation of ZnFe2O4–CuO-N/B/RGO and ZnFe2O4–CuO–C3N4 ternary heterojunction nanophotocatalyst: characterization, biocompatibility, photo-Fenton-like degradation of MO and magnetic properties
To improve the low photocatalytic efficiency, powerful UV light activation, and facile electron transport of ZnFe2O4–CuO the combination of different C3N4 and N/B/RGO nanosheets in ZnFe2O4–CuO–C3N4 and ZnFe2O4–Cu...
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Article
Heterojunction of N/B/RGO and g-C3N4 anchored magnetic ZnFe2O4@ZnO for promoting UV/Vis-induced photo-catalysis and in vitro toxicity studies
To promote the low photocatalytic efficiency caused by the recombination of electron/hole pairs and widen the photo-response wavelength window, ZnFe2O4@ZnO-N/B/RGO and ZnFe2O4@ZnO-C3N4 ternary heterojunction nano...
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Article
The immunopathobiology of T cells in stress condition: a review
Several factors impact the immune responses such as the chemical nature of antigens, the physiologic and metabolic condition of the responsive cells, the site of antigen recognition, and neuroendocrine and pha...
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Simple synthesis and characterization of Li0.5Fe2.5O4, LiMg0.5Fe2O4 and LiNi0.5Fe2O4, and investigation of their photocatalytic and anticancer properties on hela cells line
In the present work, the anticancer, photocatalytic and magnetic qualities of nanocrystalline nickel or magnesium-doped nanoparticles of lithium-ferrite samples, formed through sol–gel auto-combustion process ...
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Assessing the magnetic, cytotoxic and photocatalytic influence of incorporating Yb3+ or Pr3+ ions in cobalt–nickel ferrite
Yb3+- and Pr3+-substituted cobalt–nickel ferrite nanoparticles were prepared through a sol–gel auto-combustion procedure and the effects on the cytotoxic, photocatalytic and magnetic characteristics of the result...
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Article
Cytotoxicity and Antibacterial Effect of Trp-Substituted CM11 Cationic Peptide Against Drug-Resistant Isolates of Brucella melitensis Alone and in Combination with Recommended Antibiotics
During the recent years, antibiotic resistance of pathogenic bacteria to conventional and common antibiotics has considered as a global concern. Therefore, researchers attend to find a new class of antimicrobi...
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Article
Inducing Apoptosis and Decreasing Cell Proliferation in Human Acute Promyelocytic Leukemia Through Regulation Expression of CASP3 by Let-7a-5p Blockage
MicroRNAs (miRNAs) are short and single strand non-coding RNAs that involved in post-transcriptional regulation of gene expression. Dysregulation of miRNA expression is important event in the many of malignant...
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Article
In silico designing, cloning, and heterologous expression of novel chimeric human B lymphocyte CD20 extra loop
Design and production of monoclonal antibody for the diagnosis and immunotherapy of non-Hodgkin lymphoma require a suitable CD20 antigen as an effective immunogen. In this study, a new chimeric human CD20 extr...
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TB trifusion antigen adsorbed on calcium phosphate nanoparticles stimulates strong cellular immunity in mice
Among various vaccine candidates, subunit vaccines play an important role in immune protection against tuberculosis (TB). Calcium phosphate (CP) is considered as a strong inorganic adjuvant due to its great po...
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Investigation of the antibacterial activity of a short cationic peptide against multidrug-resistant Klebsiella pneumoniae and Salmonella typhimurium strains and its cytotoxicity on eukaryotic cells
With the growing microbial resistance to conventional antimicrobial agents, the development of novel and alternative therapeutic strategies are vital. During recent years novel peptide antibiotics with broad ...
