10 Result(s)

Article

Stiffness and axial pain are associated with the progression of calcification in a mouse model of diffuse idiopathic skeletal hyperostosis

Diffuse idiopathic skeletal hyperostosis (DISH) is characterized by progressive calcification of spinal tissues; however, the impact of calcification on pain and function is poorly understood. This study exami...

Dale E. Fournier, Matthew A. Veras, Courtney R. Brooks… in Arthritis Research & Therapy (2023)

Article

Diet-induced obesity leads to behavioral indicators of pain preceding structural joint damage in wild-type mice

Obesity is one of the largest modifiable risk factors for the development of musculoskeletal diseases, including intervertebral disc (IVD) degeneration and back pain. Despite the clinical association, no studi...

Geoffrey J. Kerr, Bethia To, Ian White, Magali Millecamps… in Arthritis Research & Therapy (2021)

Article

Overlap** signatures of chronic pain in the DNA methylation landscape of prefrontal cortex and peripheral T cells

We tested the hypothesis that epigenetic mechanisms in the brain and the immune system are associated with chronic pain. Genome-wide DNA methylation assessed in 9 months post nerve-injury (SNI) and Sham rats, ...

Renaud Massart, Sergiy Dymov, Magali Millecamps, Matthew Suderman… in Scientific Reports (2016)

Article

The epigenetic signature of chronic pain in the mouse brain

Maral Tajerian, Sebastian Alvarado, Magali Millecamps, Moshe Szyf… in Molecular Pain (2014)

Article

Alleviation of chronic neuropathic pain by environmental enrichment in mice well after the establishment of chronic pain

In animal models, the impact of social and environmental manipulations on chronic pain have been investigated in short term studies where enrichment was implemented prior to or concurrently with the injury. Th...

Pascal Vachon, Magali Millecamps, Lucie Low… in Behavioral and Brain Functions (2013)

Article

Peripheral nerve injury is accompanied by chronic transcriptome-wide changes in the mouse prefrontal cortex

Peripheral nerve injury can have long-term consequences including pain-related manifestations, such as hypersensitivity to cutaneous stimuli, as well as affective and cognitive disturbances, suggesting the inv...

Sebastian Alvarado, Maral Tajerian, Magali Millecamps, Mathew Suderman… in Molecular Pain (2013)

Article

DNA methylation of SPARC and chronic low back pain

The extracellular matrix protein SPARC (Secreted Protein, Acidic, Rich in Cysteine) has been linked to degeneration of the intervertebral discs and chronic low back pain (LBP). In humans, SPARC protein express...

Maral Tajerian, Sebastian Alvarado, Magali Millecamps, Thomas Dashwood… in Molecular Pain (2011)

Article

Cutaneous tactile allodynia associated with microvascular dysfunction in muscle

Cutaneous tactile allodynia, or painful hypersensitivity to mechanical stimulation of the skin, is typically associated with neuropathic pain, although also present in chronic pain patients who do not have evi...

Andre Laferrière, Magali Millecamps, Dimitris N Xanthos, Wen Hua **ao… in Molecular Pain (2008)