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  1. Article

    Open Access

    Power calculation for detecting interaction effect in cross-sectional stepped-wedge cluster randomized trials: an important tool for disparity research

    The stepped-wedge cluster randomized trial (SW-CRT) design has become popular in healthcare research. It is an appealing alternative to traditional cluster randomized trials (CRTs) since the burden of logistic...

    Chen Yang, Asem Berkalieva, Madhu Mazumdar… in BMC Medical Research Methodology (2024)

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  2. No Access

    Article

    Peripheral nerve block use in ankle arthroplasty and ankle arthrodesis: utilization patterns and impact on outcomes

    Ankle arthrodesis and total ankle arthroplasty (TAA) are often associated with significant postoperative pain. While this may be mitigated by the use of peripheral nerve blocks (PNB), large-scale data are lack...

    Jimmy J. Chan, Evan Garden, Jesse C. Chan, Jashvant Poeran… in Journal of Anesthesia (2021)

  3. No Access

    Article

    Trends in neoadjuvant chemotherapy versus surgery-first in stage I HER2-positive breast cancer patients in the National Cancer DataBase (NCDB)

    Neoadjuvant chemotherapy (NAC) is the standard of care for locally advanced HER2 + breast cancer (BC). Optimal sequencing of treatment (NAC vs. surgery first) is less clear cut in stage I (T1N0) HER2 + BC, whe...

    Michael Zeidman, Hank Schmidt… in Breast Cancer Research and Treatment (2021)

  4. No Access

    Article

    Use of neoadjuvant versus adjuvant chemotherapy for hormone receptor-positive breast cancer: a National Cancer Database (NCDB) study

    Neoadjuvant chemotherapy (NAC) is a well-established therapeutic option for patients with locally advanced disease often allowing downstaging and facilitation of breast conserving therapy. With evolution of be...

    Michael Zeidman, J. Jaime Alberty-Oller, Meng Ru… in Breast Cancer Research and Treatment (2020)

  5. No Access

    Article

    A Cross-sectional Study of Hospital Performance on ICU Utilization Practices for Patients with Chronic Obstructive Pulmonary Disease

    Intensive care unit (ICU) resources are a costly but effective commodity used in the management of critically ill patients with chronic obstructive pulmonary disease (COPD). ICU admission decisions are determi...

    Kusum S. Mathews, Neha N. Goel, Carmen Vargas-Torres, Ashley D. Olson, **g Zhou… in Lung (2020)

  6. Article

    Open Access

    Comparison of statistical and machine learning models for healthcare cost data: a simulation study motivated by Oncology Care Model (OCM) data

    The Oncology Care Model (OCM) was developed as a payment model to encourage participating practices to provide better-quality care for cancer patients at a lower cost. The risk-adjustment model used in OCM is ...

    Madhu Mazumdar, Jung-Yi Joyce Lin, Wei Zhang, Lihua Li… in BMC Health Services Research (2020)

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  7. No Access

    Article

    Can an Emergency Department Observation Unit Reduce Hospital Admissions for COPD Exacerbation?

    Studies on observation unit (OU) use to avoid a hospital admission from the emergency department (ED) have found variable effects on health care resource utilization, and these effects have not been studied in...

    Julia Budde, Parul Agarwal, Madhu Mazumdar, Jonathan Yeo, Sidney S. Braman in Lung (2018)

  8. No Access

    Article

    Association of opioid prescription and perioperative complications in obstructive sleep apnea patients undergoing total joint arthroplasties

    Obstructive sleep apnea (OSA) has been linked to higher rates of perioperative complications. Practice guidelines recommend minimizing opioids in this cohort to reduce complications. However, a paucity of evid...

    Eva E. Mörwald, Ashley Olson, Crispiana Cozowicz, Jashvant Poeran… in Sleep and Breathing (2018)

  9. Article

    Open Access

    Impact of correlation of predictors on discrimination of risk models in development and external populations

    The area under the ROC curve (AUC) of risk models is known to be influenced by differences in case-mix and effect size of predictors. The impact of heterogeneity in correlation among predictors has however bee...

    Suman Kundu, Madhu Mazumdar, Bart Ferket in BMC Medical Research Methodology (2017)

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  10. No Access

    Article

    Preoperative radiographic parameters predict long-term renal impairment following partial nephrectomy

    We analyzed radiographic parameters describing anatomic features of renal tumors to identify preoperative characteristics that could help predict long-term decline in renal function following partial nephrectomy.

    Eugene K. Cha, Casey K. Ng, Bryan Jeun, Allison Dunning… in World Journal of Urology (2013)

  11. No Access

    Article

    Breast Cancer Subtypes in Asian-Americans Differ According to Asian Ethnic Group

    Breast cancer prognosis and breast cancer molecular subtype vary by race/ethnicity. We determined whether the distribution of breast cancer subtypes varies among different Asian ethnic groups. Using immunohist...

    Ellen Chuang, Paul Christos, Arielle Flam… in Journal of Immigrant and Minority Health (2012)

  12. No Access

    Article

    Visualization of the normal appendix with MR enterography in children

    Magnetic resonance (MR) imaging may provide a radiation-sparing alternative to CT in diagnosing appendicitis in children in whom US is equivocal. However, comparability with CT in the detection of the appendix...

    Arzu Kovanlikaya, Daniel Rosenbaum, Madhu Mazumdar, Allison Dunning… in Pediatric Radiology (2012)

  13. Article

    Open Access

    Is there a role for expectation maximization imputation in addressing missing data in research using WOMAC questionnaire? Comparison to the standard mean approach and a tutorial

    Standard mean imputation for missing values in the Western Ontario and Mc Master (WOMAC) Osteoarthritis Index limits the use of collected data and may lead to bias. Probability model-based imputation methods o...

    Hassan MK Ghomrawi, Lisa A Mandl, John Rutledge… in BMC Musculoskeletal Disorders (2011)

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  14. No Access

    Article

    Metabolic surgery: the role of the gastrointestinal tract in diabetes mellitus

    Mounting evidence suggests that gastrointestinal surgical procedures, such as gastric bypass, can induce long-term remission of type 2 diabetes mellitus (T2DM) and other metabolic disorders. Here, Rubino and c...

    Francesco Rubino, Sarah L. R'bibo, Federica del Genio… in Nature Reviews Endocrinology (2010)

  15. No Access

    Article

    Phase II Trial of Temozolomide in Patients with Cisplatin-Refractory Germ Cell Tumors

    Fourteen patients with cisplatin-refractory germ cell tumors (GCT) were treated with temozolomide on a phase II trial. Temozolomide was given orally at 150 mg/m2/day on days 1–5. The cycle length was 28 days. No ...

    G. Varuni Kondagunta, Jennifer Bacik, Lawrence Schwartz… in Investigational New Drugs (2004)

  16. No Access

    Article

    Phase II trial of ZD1839 (IRESSA™) in patients with advanced renal cell carcinoma

    Eighteen patients with advanced renal cell carcinoma (RCC) were treated on a phase II trial with ZD1839 (IRESSA). Treatment efficacy was determined using the endpoint of improvement in time to progression (TTP...

    Beverly Drucker, Jennifer Bacik, Michelle Ginsberg… in Investigational New Drugs (2003)

  17. No Access

    Article

    Phase II Trial of Irofulven (6-Hydroxymethylacylfulvene) for Patients with Advanced Renal Cell Carcinoma

    The aim of this study was to determine the antitumor activityof irofulven (6-hydroxymethylacylfulvene) in patients withadvanced renal cell carcinoma (RCC). Eligible patients hadadvanced renal cell carcinoma wi...

    William J. Berg, Lawrence Schwartz, Richard Yu, Madhu Mazumdar… in Investigational New Drugs (2001)

  18. No Access

    Article

    Phase II Trial of Pyrazoloacridine as Second-Line Therapy for Patients with Unresectable or Metastatic Transitional Cell Carcinoma

    Purpose: A phase II trial of pyrazoloacridine(PZA) was conducted to assess its activity andtoxicity in patients with advanced transitional cellcarcinoma (TCC) refractory to or progressing after oneprior cisplati...

    Paul M. Dodd, John A. McCaffrey, Madhu Mazumdar… in Investigational New Drugs (2000)

  19. No Access

    Article

    A phase II study of pyrazoloacridine in patients with advanced renal cell carcinoma

    The aim of this study was to determine the antitumor activity of pyrazoloacridine in patients with renal cell carcinoma. Eligible patients had advanced renal cell carcinoma with bidimensionally measurable dise...

    William J. Berg, John McCaffrey, Lawrence H. Schwartz… in Investigational New Drugs (1998)

  20. No Access

    Article

    A Phase II study of 13-cis-retinoic acid in patients with advanced renal cell carcinoma

    The aim of this study was to determine the antitumor activity of 13-cis-retinoic acid as a single agent in patients with advanced renal cell carcinoma. Eligible patients had advanced renal cell carcinoma with ...

    William J. Berg, Lawrence H. Schwartz, Alison Amsterdam… in Investigational New Drugs (1997)