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Article
Medicaid expansion in California and breast cancer incidence across neighborhoods with varying social vulnerabilities
To investigate changes in breast cancer incidence rates associated with Medicaid expansion in California.
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Article
Open AccessPower calculation for detecting interaction effect in cross-sectional stepped-wedge cluster randomized trials: an important tool for disparity research
The stepped-wedge cluster randomized trial (SW-CRT) design has become popular in healthcare research. It is an appealing alternative to traditional cluster randomized trials (CRTs) since the burden of logistic...
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Reference Work Entry In depth
Diagnostic Trials
The term diagnostic trial is generally used in two different ways. A diagnostic trial type I describes studies that evaluate accuracy of diagnostic tests in detecting disease or its severity. Primary endpoints fo...
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Article
Peripheral nerve block use in ankle arthroplasty and ankle arthrodesis: utilization patterns and impact on outcomes
Ankle arthrodesis and total ankle arthroplasty (TAA) are often associated with significant postoperative pain. While this may be mitigated by the use of peripheral nerve blocks (PNB), large-scale data are lack...
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Article
Trends in neoadjuvant chemotherapy versus surgery-first in stage I HER2-positive breast cancer patients in the National Cancer DataBase (NCDB)
Neoadjuvant chemotherapy (NAC) is the standard of care for locally advanced HER2 + breast cancer (BC). Optimal sequencing of treatment (NAC vs. surgery first) is less clear cut in stage I (T1N0) HER2 + BC, whe...
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Article
Develo** an Institute for Health Care Delivery Science: successes, challenges, and solutions in the first five years
Medical knowledge is increasing at an exponential rate. At the same time, unexplained variations in practice and patient outcomes and unacceptable rates of medical errors and inefficiencies in health care deli...
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Chapter
Team Science in Biostatistical Collaboration: An Opportunity to Practice Leadership, Embrace Diversity, Manage Conflict, and Share Credit
Multidisciplinary scientific teams are crucial for addressing formidable health problems. The increasing need to design, collect, analyze, and interpret health data places biostatisticians at the center of tea...
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Living Reference Work Entry In depth
Diagnostic Trials
The term diagnostic trial is generally used in two different ways. A diagnostic trial type I describes studies that evaluate accuracy of diagnostic tests in detecting disease or its severity. Primary endpoints fo...
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Article
Use of neoadjuvant versus adjuvant chemotherapy for hormone receptor-positive breast cancer: a National Cancer Database (NCDB) study
Neoadjuvant chemotherapy (NAC) is a well-established therapeutic option for patients with locally advanced disease often allowing downstaging and facilitation of breast conserving therapy. With evolution of be...
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Article
An inflammatory cytokine signature predicts COVID-19 severity and survival
Several studies have revealed that the hyper-inflammatory response induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a major cause of disease severity and death. However, predictive bi...
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Article
A Cross-sectional Study of Hospital Performance on ICU Utilization Practices for Patients with Chronic Obstructive Pulmonary Disease
Intensive care unit (ICU) resources are a costly but effective commodity used in the management of critically ill patients with chronic obstructive pulmonary disease (COPD). ICU admission decisions are determi...
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Article
Open AccessComparison of statistical and machine learning models for healthcare cost data: a simulation study motivated by Oncology Care Model (OCM) data
The Oncology Care Model (OCM) was developed as a payment model to encourage participating practices to provide better-quality care for cancer patients at a lower cost. The risk-adjustment model used in OCM is ...
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Article
Can an Emergency Department Observation Unit Reduce Hospital Admissions for COPD Exacerbation?
Studies on observation unit (OU) use to avoid a hospital admission from the emergency department (ED) have found variable effects on health care resource utilization, and these effects have not been studied in...
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Article
Association of opioid prescription and perioperative complications in obstructive sleep apnea patients undergoing total joint arthroplasties
Obstructive sleep apnea (OSA) has been linked to higher rates of perioperative complications. Practice guidelines recommend minimizing opioids in this cohort to reduce complications. However, a paucity of evid...
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Article
Open AccessImpact of correlation of predictors on discrimination of risk models in development and external populations
The area under the ROC curve (AUC) of risk models is known to be influenced by differences in case-mix and effect size of predictors. The impact of heterogeneity in correlation among predictors has however bee...
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Article
Preoperative radiographic parameters predict long-term renal impairment following partial nephrectomy
We analyzed radiographic parameters describing anatomic features of renal tumors to identify preoperative characteristics that could help predict long-term decline in renal function following partial nephrectomy.
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Article
Breast Cancer Subtypes in Asian-Americans Differ According to Asian Ethnic Group
Breast cancer prognosis and breast cancer molecular subtype vary by race/ethnicity. We determined whether the distribution of breast cancer subtypes varies among different Asian ethnic groups. Using immunohist...
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Article
Visualization of the normal appendix with MR enterography in children
Magnetic resonance (MR) imaging may provide a radiation-sparing alternative to CT in diagnosing appendicitis in children in whom US is equivocal. However, comparability with CT in the detection of the appendix...
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Article
Open AccessIs there a role for expectation maximization imputation in addressing missing data in research using WOMAC questionnaire? Comparison to the standard mean approach and a tutorial
Standard mean imputation for missing values in the Western Ontario and Mc Master (WOMAC) Osteoarthritis Index limits the use of collected data and may lead to bias. Probability model-based imputation methods o...
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Article
Open AccessIncreased shedding of HU177 correlates with worse prognosis in primary melanoma
Increased levels of cryptic collagen epitope HU177 in the sera of melanoma patients have been shown to be associated with thicker primary melanomas and with the nodular histologic subtype. In this study, we in...
