31 Result(s)
within
Małgorzata Frankowska
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Article
Further proof on the role of accumbal nNOS in cocaine-seeking behavior in rats
Cocaine use disorder (CUD) remains a severe health problem with no effective pharmacological therapy. One of the potential pharmacological strategies for CUD pharmacotherapy includes manipulations of the brain...
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Article
Open AccessEvaluation of the 5-HT2C receptor drugs RO 60-0175, WAY 161503 and mirtazepine in a preclinical model of comorbidity of depression and cocaine addiction
Epidemiological data indicate a high rate of comorbidity of depression and cocaine use disorder (CUD). The role of serotonin 2C (5-HT2C) receptors in the mechanisms responsible for the coexistence of depression a...
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Living Reference Work Entry In depth
Heteroreceptor Complexes in Substance Use Disorders
Substance use disorder (SUD) is a chronic and serious brain disorder. Several drugs can lead to addictive behavior including psychostimulants, opioids, cannabinoids (CB), nicotine, and alcohol. Their behavioral o...
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Reference Work Entry In depth
Heteroreceptor Complexes in Substance Use Disorders
Substance use disorder (SUD) is a chronic and serious brain disorder. Several drugs can lead to addictive behavior including psychostimulants, opioids, cannabinoids (CB), nicotine, and alcohol. Their behavioral o...
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Article
Open AccessTreatment with dopamine β-hydroxylase (DBH) inhibitors prevents morphine use and relapse-like behavior in rats
Opioid use disorders are serious contributors to the harms associated with the drug use. Unfortunately, therapeutic interventions for opioid addicts after detoxification have been limited and not sufficiently ...
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Article
Correction to: The coming together of allosteric and phosphorylation mechanisms in the molecular integration of A2A heteroreceptor complexes in the dorsal and ventral striatal-pallidal GABA neurons
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Article
Open AccessN-acetylcysteine in substance use disorder: a lesson from preclinical and clinical research
Substance use disorder (SUD) is a chronic brain condition, with compulsive and uncontrollable drug-seeking that leads to long-lasting and harmful consequences. The factors contributing to the development of SU...
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Article
Open AccessThe coming together of allosteric and phosphorylation mechanisms in the molecular integration of A2A heteroreceptor complexes in the dorsal and ventral striatal-pallidal GABA neurons
The role of adenosine A2A receptor (A2AR) and striatal-enriched protein tyrosine phosphatase (STEP) interactions in the striatal-pallidal GABA neurons was recently discussed in relation to A2AR overexpression ...
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Article
Open AccessThe NMDA Receptor Subunit (GluN1 and GluN2A) Modulation Following Different Conditions of Cocaine Abstinence in Rat Brain Structures
Different neuronal alterations within glutamatergic system seem to be crucial for develo** of cocaine-seeking behavior. Cocaine exposure provokes a modulation of the NMDA receptor subunit expression in roden...
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Article
Correction to: Extinction training following cocaine or MDMA self-administration produces discrete changes in D2-like and mGlu5 receptor density in the rat brain
In this published article, Fig. 5 contained a mistake—graphs on the right
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Article
Extinction training following cocaine or MDMA self-administration produces discrete changes in D2-like and mGlu5 receptor density in the rat brain
Several studies strongly support the role of the dopamine D2-like and glutamate mGlu5 receptors in psychostimulant reward and relapse.
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Article
Open AccessEffects of Cocaine Self-Administration and Its Extinction on the Rat Brain Cannabinoid CB1 and CB2 Receptors
The aim of this study was to evaluate changes in the expression of cannabinoid type 1 (CB1) and 2 (CB2) receptor proteins in several brain regions in rats undergoing cocaine self-administration and extinction ...
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Article
Open AccessThe Alterations in Mitochondrial DNA Copy Number and Nuclear-Encoded Mitochondrial Genes in Rat Brain Structures after Cocaine Self-Administration
The repeated intake of cocaine evokes oxidative stress that is present even during drug withdrawal. Recent studies demonstrate that cocaine-induced oxidative and/or endoplasmic reticulum stress can affect mito...
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Article
Open AccessCocaine Administration and Its Withdrawal Enhance the Expression of Genes Encoding Histone-Modifying Enzymes and Histone Acetylation in the Rat Prefrontal Cortex
Chronic exposure to cocaine, craving, and relapse are attributed to long-lasting changes in gene expression arising through epigenetic and transcriptional mechanisms. Although several brain regions are involve...
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Article
Open AccessProlonged Induction of miR-212/132 and REST Expression in Rat Striatum Following Cocaine Self-Administration
Chronic exposure to cocaine in vivo induces long-term synaptic plasticity associated with the brain’s circuitry that underlies development of repetitive and automatic behaviors called habits. In fact, prolonge...
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Article
Acute behavioral effects of co-administration of mephedrone and MDMA in mice
Abuse of more than one psychoactive drug is becoming a global problem. Our experiments were designed to examine the effects of a concomitant administration of 3,4-methylenedioxy-methamphetamine (MDMA) and meph...
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Chapter
Targeting the GABAB Receptor for the Treatment of Substance Use Disorder
This chapter reviews the current preclinical research on the significance of central γ-amino butyric acid (GABA)B receptors in substance use disorder (SUD) and the SUD potential pharmacotherapy based on GABAB rec...
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Article
Cocaine exposure alters H2S tissue concentrations in peripheral mouse organs
Hydrogen sulfide (H2S) is well-known as a physiological mediator in the mammalian brain and peripheral tissues. Among several factors that change the concentration of H2S, oxidative stress and generation of react...
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Article
Open AccessWithdrawal from Cocaine Self-administration and Yoked Cocaine Delivery Dysregulates Glutamatergic mGlu5 and NMDA Receptors in the Rat Brain
In human addicts and in animal models, chronic cocaine use leads to numerous alterations in glutamatergic transmission, including its receptors. The present study focused on metabotropic glutamatergic receptor...
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Article
The effect of active and passive intravenous cocaine administration on the extracellular signal-regulated kinase (ERK) activity in the rat brain
According to a current hypothesis of learning processes, recent papers pointed out to an important role of the extracellular signal-regulated kinase (ERK), in drug addiction. We employed the Western blotting t...
