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Article
Pharmacokinetics of prazepam in man
An original electron-capture gas chromatographic assay was developed for simultaneous measurement of plasma levels of the benzodiazepine derivative prazepam and of its principal unconjugated metabolite, N-desm...
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Article
The use of an inexpensive, general purpose microcomputer in quantitative cytochemistry
A 32 K Commodore Pet microcomputer has been interfaced with two Vickers microdensitometers. This system allows for the simultaneous logging of data from two densitometers being operated independently of each o...
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Article
The pharmacokinetics of midazolam in man
Midazolam, a new water-soluble benzodiazepine, was administered as: i) 5 mg intravenously, ii) a 10-mg oral solution and iii) a 10-mg oral tablet, to six volunteers whose informed consent had been obtained. Mi...
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Article
The unsteady model
In this paper an alternative approach to nonlinear pharmacokinetic modelling has been developed from first principles. This “Unsteady Model” is able to describe the situation whereby one or more independent dr...
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Article
The influence on enzyme activity of storage of tissue blocks at −70° C
Blocks of tissue from various organs of the rat have been chilled by precipitate immersion in n-hexane cooled to −70° C, and then stored at −70° C. At various intervals (up to 14 days) after chilling, cryostat...
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Article
Chronic propranolol administration during pregnancy
The pharmacokinetics of propranolol (P) and its major metabolites, propranolol glucuronide (PGLUC), 4-hydroxypropranolol (4OHP), 4-hydroxypropranolol glucuronide (4OHPGLUC) and naphthoxylactic acid (NLA), (Wal...
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Article
Metabolism of propranolol in the human maternal-placental-foetal unit
Propranolol (P) and all of its major known metabolites were found in maternal plasma, cord plasma and neonatal plasma in 10 women at term, irrespective of the P doses administered and the time elapsed (up to 1...
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Article
Bioavailability and pharmacokinetics of phenytoin during pregnancy
Five epileptic women needing to commence phenytoin therapy during pregnancy received a single intravenous and a single oral dose of phenytoin several days apart before starting regular intake of the drug. Plas...
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Article
Pharmacokinetics of midazolam in the aged
The pharmacokinetics of midazolam, an imidazo-benzodiazepine derivative, have been studied in 13 subjects over the age of 60 years who received the drug intravenously (0.07 mg kg−1) as an induction agent for endo...
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Article
Bioavailability and pharmacokinetics of phenytoin during pregnancy
Five epileptic women needing to commence phenytoin therapy during pregnancy received a single intravenous and a single oral dose of phenytoin several days apart before starting regular intake of the drug. Plas...
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Article
Correlations between in vitro dissolution, in vivo bioavailability and hypoglycaemic effect of oral glibenclamide
A study has been carried out investigating four different marketed oral preparations of glibenclamide, correlating the effectiveness of the drug in these preparations in lowering plasma glucose concentrations ...
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Article
Antennal olfactory responsiveness of three sympatricIps species [Ips avulsus (Eichhoff),Ips calligraphus (Germar),Ips grandicollis (Eichhoff)], to intra- and interspecific behavioral chemicals
Electroantennograms (EAGs) from male and femaleIps avulsus, I. calligraphus, andI. grandicollis to their pheromones and selected host odorants or kairomones verified the presence of antennal olfactory receptors i...
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Article
The effect of ethylene on RNA and protein synthesis in germinating Manketti (Ricinodendron rautanenii Schinz) seeds
Amino acid uptake and protein synthesis were monitored in the embryonic axis, cotyledons and endosperm of manketti seeds (Ricinodendron rautanenii Schinz) during imbition, dormancy and dormancy-breaking by ethyle...
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Article
X-Ray Diffraction Analysis of Heteroepitaxial Cd1-yZnyTe on GaAs
X-ray diffraction techniques were used to evaluate Cd1-yZnyTe grown on GaAs substrate orientations of {100}2°, {111}, {012}, and {123}. High-quality layers having compositions at or close to the CdTe and ZnTe bin...
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Article
Sex pheromone of hickory shuckwormCydia caryana Development of an effective field Lure
Extracts of the sex pheromone glands of femaleCydia caryana were evaluated by electroantennography and gas chromatography-mass spectrometry. These studies suggested the following compounds were potential sex pher...
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Article
Olfactory-based behavioral interactions among five species in the southern pine bark beetle group
Olfactory-mediated behavioral interactions were investigated among the five scolytid species comprising the southern pine bark beetle group. Behavioral response, as determined from field trap catch data, showe...
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Article
Estimating the proportion of migrants from Anglican marriage registers
Anglican marriage registers are the only source to allow a comprehensive survey of migration rates in England from the sixteenth century to the present day. However, a comparison with estimates from annotated ...
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Article
A 7-year review of maxillofacial trauma in a central London hospital'
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Article
Effect of gibberellic acid on carnation flower senescence: evidence that the delay of carnation flower senescence by gibberellic acid depends on the stage of flower development
Gibberellic acid at concentrations of 10−5 M and 10−4 M delayed the senescence of cut carnation flowers, when applied continuously via the stem, to flowers between the closed brush and fully open stages of develo...
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Article
Myxozyma vanderwaltii sp. nov. (Candidaceae), a new yeast species isolated from a flower ofProtea repens (L.) L.
Three strains of an undescribed species of the genusMyxozyma were recovered. The new species differs from other accepted species of the genus in its assimilation pattern of carbon sources, mol% G + C and low DNA-...
