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  1. Article

    Open Access

    Prostate cancer induced bone pain: pathobiology, current treatments and pain responses from recent clinical trials

    Metastatic spread of prostate cancer to the skeleton may result in debilitating bone pain. In this review, we address mechanisms underpinning the pathobiology of metastatic prostate cancer induced bone pain (P...

    A. E. Smith, A. Muralidharan, M. T. Smith in Discover Oncology (2022)

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  2. No Access

    Living Reference Work Entry In depth

    Side Effects of Central Analgesic Drugs

    Strong opioid analgesics, such as morphine, are the most widely used, centrally acting class of analgesics that are available in the clinic for the treatment of moderate to severe acute nociceptive pain and ch...

    M. Z. Imam, A. Kuo, M. T. Smith in Drug Discovery and Evaluation: Safety and …

  3. No Access

    Article

    Follicular lymphoma-protective HLA class II variants correlate with increased HLA-DQB1 protein expression

    Multiple follicular lymphoma (FL) susceptibility single-nucleotide polymorphisms in the human leukocyte antigen (HLA) class I and II regions have been identified, including rs6457327, rs3117222, rs2647012, rs1...

    F C M Sillé, L Conde, J Zhang, N K Akers, S Sanchez, J Maltbaek… in Genes & Immunity (2014)

  4. No Access

    Article

    Leukemia-related chromosomal loss detected in hematopoietic progenitor cells of benzene-exposed workers

    Benzene exposure causes acute myeloid leukemia and hematotoxicity, shown as suppression of mature blood and myeloid progenitor cell numbers. As the leukemia-related aneuploidies monosomy 7 and trisomy 8 previo...

    L Zhang, Q Lan, Z Ji, G Li, M Shen, R Vermeulen, W Guo, A E Hubbard, C M McHale… in Leukemia (2012)

  5. Article

    Open Access

    PG545, a dual heparanase and angiogenesis inhibitor, induces potent anti-tumour and anti-metastatic efficacy in preclinical models

    PG545 is a heparan sulfate (HS) mimetic that inhibits tumour angiogenesis by sequestering angiogenic growth factors in the extracellular matrix (ECM), thus limiting subsequent binding to receptors. Importantly...

    K Dredge, E Hammond, P Handley, T J Gonda, M T Smith… in British Journal of Cancer (2011)

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  6. No Access

    Article

    The RNA-binding protein La contributes to cell proliferation and CCND1 expression

    The La protein is an essential RNA-binding protein implicated in different aspects of RNA metabolism. Herein, we report that small interfering (siRNA)-mediated La depletion reduces cell proliferation of differ...

    G Sommer, J Dittmann, J Kuehnert, K Reumann, P E Schwartz, H Will, B L Coulter… in Oncogene (2011)

  7. No Access

    Article

    A comparison of the cytogenetic alterations and global DNA hypomethylation induced by the benzene metabolite, hydroquinone, with those induced by melphalan and etoposide

    Specific cytogenetic alterations and changes in DNA methylation are involved in leukemogenesis. Benzene, an established human leukemogen, is known to induce cytogenetic changes through its active metabolites i...

    Z Ji, L Zhang, V Peng, X Ren, C M McHale, M T Smith in Leukemia (2010)

  8. No Access

    Article

    Proteomic analysis of childhood leukemia

    Childhood acute lymphoblastic and myeloid leukemias are stratified into molecular and cytogenetic subgroups important for prognosis and therapy. Studies have shown that gene expression profiles can discriminat...

    C M Hegedus, L Gunn, C F Skibola, L Zhang, R Shiao, S Fu, E A Dalmasso… in Leukemia (2005)

  9. Article

    Open Access

    Non-Hodgkin's lymphoma, obesity and energy homeostasis polymorphisms

    A population-based case–control study of lymphomas in England collected height and weight details from 699 non-Hodgkin's lymphoma (NHL) cases and 914 controls. Obesity, defined as a body mass index (BMI) over ...

    E V Willett, C F Skibola, P Adamson, D R Skibola, G J Morgan… in British Journal of Cancer (2005)

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  10. No Access

    Article

    RAS mutation is associated with hyperdiploidy and parental characteristics in pediatric acute lymphoblastic leukemia

    We explored the relationship of RAS gene mutations with epidemiologic and cytogenetic factors in a case series of children with leukemia. Diagnostic bone marrow samples from 191 incident leukemia cases from the N...

    J L Wiemels, Y Zhang, J Chang, S Zheng, C Metayer, L Zhang, M T Smith, X Ma… in Leukemia (2005)

  11. No Access

    Article

    Presleep Cognitions in Patients with Insomnia Secondary to Chronic Pain

    This study had two primary objectives: (1) characterize the content of presleep cognitions of chronic pain patients and (2) evaluate the association between presleep cognitions and sleep disturbance. Thirty-on...

    M. T. Smith, M. L. Perlis, T. P. Carmody, M. S. Smith… in Journal of Behavioral Medicine (2001)

  12. No Access

    Article

    Forming-limit diagrams of aluminum tailor-welded blank weld material

    The current work develops forming-limit diagrams (FLDs) for weld materials in aluminum tailorwelded blanks (TWBs) under biaxial stretching conditions. Aluminum TWBs consist of multiple-thickness and alloy shee...

    R. W. Davies, G. J. Grant, M. A. Khaleel… in Metallurgical and Materials Transactions A (2001)

  13. No Access

    Article

    Weld metal ductility in aluminum tailor welded blanks

    The objective of the research described in this article was to characterize and numerically describe the ductility of weld material in aluminum tailor welded blanks under uniaxial tension conditions. Aluminum ...

    R. W. Davies, M. T. Smith, M. A. Khaleel… in Metallurgical and Materials Transactions A (2000)

  14. No Access

    Article

    Sleep Quality and Presleep Arousal in Chronic Pain

    This study was designed (1) to characterize the extent and nature of sleep complaints of chronic pain patients and (2) to examine the factors that predict sleep quality. A heterogeneous sample of 51 outpatient...

    M. T. Smith, M. L. Perlis, M. S. Smith, D. E. Giles… in Journal of Behavioral Medicine (2000)

  15. No Access

    Article

    Characterizing Al tailor-welded blanks for automotive applications

    The application of aluminum tailor-welded blanks offers significant potential for reducing the weight of future automobiles, and improvements are being made in the development and understanding of the welding ...

    R. W. Davies, H. E. Oliver, M. T. Smith, G. J. Grant M.S. in JOM (1999)

  16. No Access

    Article

    Diversity and affinities among species and strains of Lipomyces

    Phylogenetic relationships of the yeast genus Lipomyces were studied using sequences from fragments of 5.8S rRNA gene and from internal transcribed spacer region ITS2 of 13 strains (7 type strains included) re...

    D.E. Gouliamova, G.L. Hennebert, M.T. Smith, J.P. van der Walt in Antonie van Leeuwenhoek (1998)

  17. No Access

    Article

    Comparison of industrial yeast strains for fermentation of spent sulphite pul** liquor fortified with wood hydrolysate

    Ethanol production from spent sulphite pul** liquor (SSL) was compared for four different yeasts. A second strain of S. cerevisiae as well as a 2-deoxyglucose-resistant strain formed through protoplast fusion...

    M T Smith, D R Cameron, S J B Duff in Journal of Industrial Microbiology and Biotechnology (1997)

  18. No Access

    Article

    The effect of a plant-derived smoke extract on the germination of light-sensitive lettuce seed

    A simple and rapid bioassay using seeds of Lactuca sativa L. Grand Rapids has been developed for the detection of germination-enhancing compound(s) in plant-derived smoke extracts. This light-sensitive species ge...

    F. E. Drewes, M. T. Smith, J. van Staden in Plant Growth Regulation (1995)

  19. No Access

    Article

    Purine cytokinin nomenclature: a working system of abbreviations

    Many synonyms for the cytokinin 6-(benzylamino)purine and its metabolites have arisen in the literature despite a 1970 IUPAC-IUB directive delimiting such nomenclature. Examples of symbols and abbreviations fo...

    N. R. Crouch, M. T. Smith, J. van Staden in Plant Growth Regulation (1993)

  20. No Access

    Article

    Myxozyma vanderwaltii sp. nov. (Candidaceae), a new yeast species isolated from a flower ofProtea repens (L.) L.

    Three strains of an undescribed species of the genusMyxozyma were recovered. The new species differs from other accepted species of the genus in its assimilation pattern of carbon sources, mol% G + C and low DNA-...

    F. Spaaij, G. Weber, M. T. Smith in Antonie van Leeuwenhoek (1993)

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