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Article
RAS mutation is associated with hyperdiploidy and parental characteristics in pediatric acute lymphoblastic leukemia
We explored the relationship of RAS gene mutations with epidemiologic and cytogenetic factors in a case series of children with leukemia. Diagnostic bone marrow samples from 191 incident leukemia cases from the N...
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Article
Proteomic analysis of childhood leukemia
Childhood acute lymphoblastic and myeloid leukemias are stratified into molecular and cytogenetic subgroups important for prognosis and therapy. Studies have shown that gene expression profiles can discriminat...
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Article
A comparison of the cytogenetic alterations and global DNA hypomethylation induced by the benzene metabolite, hydroquinone, with those induced by melphalan and etoposide
Specific cytogenetic alterations and changes in DNA methylation are involved in leukemogenesis. Benzene, an established human leukemogen, is known to induce cytogenetic changes through its active metabolites i...
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Article
The RNA-binding protein La contributes to cell proliferation and CCND1 expression
The La protein is an essential RNA-binding protein implicated in different aspects of RNA metabolism. Herein, we report that small interfering (siRNA)-mediated La depletion reduces cell proliferation of differ...
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Article
Leukemia-related chromosomal loss detected in hematopoietic progenitor cells of benzene-exposed workers
Benzene exposure causes acute myeloid leukemia and hematotoxicity, shown as suppression of mature blood and myeloid progenitor cell numbers. As the leukemia-related aneuploidies monosomy 7 and trisomy 8 previo...
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Article
Open AccessProstate cancer induced bone pain: pathobiology, current treatments and pain responses from recent clinical trials
Metastatic spread of prostate cancer to the skeleton may result in debilitating bone pain. In this review, we address mechanisms underpinning the pathobiology of metastatic prostate cancer induced bone pain (P...