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  1. Article

    Open Access

    Prostate cancer induced bone pain: pathobiology, current treatments and pain responses from recent clinical trials

    Metastatic spread of prostate cancer to the skeleton may result in debilitating bone pain. In this review, we address mechanisms underpinning the pathobiology of metastatic prostate cancer induced bone pain (P...

    A. E. Smith, A. Muralidharan, M. T. Smith in Discover Oncology (2022)

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  2. No Access

    Article

    Leukemia-related chromosomal loss detected in hematopoietic progenitor cells of benzene-exposed workers

    Benzene exposure causes acute myeloid leukemia and hematotoxicity, shown as suppression of mature blood and myeloid progenitor cell numbers. As the leukemia-related aneuploidies monosomy 7 and trisomy 8 previo...

    L Zhang, Q Lan, Z Ji, G Li, M Shen, R Vermeulen, W Guo, A E Hubbard, C M McHale… in Leukemia (2012)

  3. No Access

    Article

    A comparison of the cytogenetic alterations and global DNA hypomethylation induced by the benzene metabolite, hydroquinone, with those induced by melphalan and etoposide

    Specific cytogenetic alterations and changes in DNA methylation are involved in leukemogenesis. Benzene, an established human leukemogen, is known to induce cytogenetic changes through its active metabolites i...

    Z Ji, L Zhang, V Peng, X Ren, C M McHale, M T Smith in Leukemia (2010)

  4. No Access

    Article

    Proteomic analysis of childhood leukemia

    Childhood acute lymphoblastic and myeloid leukemias are stratified into molecular and cytogenetic subgroups important for prognosis and therapy. Studies have shown that gene expression profiles can discriminat...

    C M Hegedus, L Gunn, C F Skibola, L Zhang, R Shiao, S Fu, E A Dalmasso… in Leukemia (2005)

  5. No Access

    Article

    RAS mutation is associated with hyperdiploidy and parental characteristics in pediatric acute lymphoblastic leukemia

    We explored the relationship of RAS gene mutations with epidemiologic and cytogenetic factors in a case series of children with leukemia. Diagnostic bone marrow samples from 191 incident leukemia cases from the N...

    J L Wiemels, Y Zhang, J Chang, S Zheng, C Metayer, L Zhang, M T Smith, X Ma… in Leukemia (2005)