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Article
Open AccessUV light-blocking contact lenses protect against short-term UVB-induced limbal stem cell niche damage and inflammation
UVB irradiation has been linked to pathogenesis of pterygium, a conjunctival tumor growing onto transparent cornea, the windscreen of the eye. Due to corneal anatomy, ambient UVB irradiation is amplified at th...
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Article
Stammzell-basierter biologischer Gefäßersatz
Eine chronisch-kritische Ischämie bei Patienten mit zugrunde liegender arterieller Verschlusskrankheit erfordert rekonstruktive vaskuläre chirurgische Eingriffe, die bislang mit körpereigenen Venensegmenten od...
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Article
Open AccessPositional OSA part 2: retrospective cohort analysis with a new classification system (APOC)
In Part 1 of this two-part article, the Amsterdam Positional Obstructive Sleep Apnoea Classification (APOC) was recently introduced, a classification system aimed at facilitating the identification of suitable...
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Article
Positional OSA part 1: towards a clinical classification system for position-dependent obstructive sleep apnoea
In 1984, Cartwright suggested that physicians should differentiate between patients with either positional obstructive sleep apnoea (POSA) or non-positional OSA. Treatment of POSA has advanced dramatically rec...
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Chapter and Conference Paper
Identification of pancreatic cancer initiating cells: The role of the MDR gene ABCB5
Tumor initiation and growth result from the formation of cancer initiating cells, also known as cancer stem cells (CSC). ABCB5 is a novel human multidrug resistance mediator. We recently showed that ABCB5 iden...
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Chapter and Conference Paper
Chronic inflammation and tumor progression: Analysis of Toll-like receptor expression in colorectal carcinoma
Chronic inflammation and infection are the most important epigenetic and environmental factors leading to tumorigenesis and tumor progression. The Toll-like receptor (TLR) family is a group of receptors involv...
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Article
Investigation of multidrug resistance in cultured human renal cell carcinoma cells by 31P-NMR spectroscopy and treatment survival assays
KTCTL-26 and KTCTL-2 are renal cell carcinoma (RCC) lines with high and lowexpression of P-170 glycoprotein, respectively. Inherent differences between the two cell lines in terms of phosphate metabolites and ...
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Article
X-ray structure analysis of a nickel-petroporphyrin confirms hypothesis of treibs