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Article
A Facile Synthesis of 3,5-Dibenzylidene-1-(1-benzyl-1H-1,2,3-triazol-4-ylmethyl)piperidin-4-ones
A new copper(I) catalytic system has been developed for the alkyne–azide click reaction. 3,5-Dibenzylidene-1-(prop-2-yn-1-yl)piperidin-4-ones reacted with alkyl azides in water–tert-butyl alcohol (1:1) in the pre...
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Article
Design, Synthesis, and Anticancer Activity of Amide Derivatives of Structurally Modified Combretastatin-A4
A new series of amide derivatives of structurally modified combretastatin-A4 10a–10j are synthesized, and their structures are confirmed by 1H and 13C NMR, and mass spectral data. The products are tested for thei...
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Chapter and Conference Paper
Process Parameters Optimization of Cylindrical Grinding Machining Using Taguchi Method
The main objective of this work is to study the effect of material hardness, workpiece speed and depth of cut on surface finish and material removal rate in cylindrical grinding process. For three process para...
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Article
Assessment and Reporting of the Clinical Immunogenicity of Therapeutic Proteins and Peptides—Harmonized Terminology and Tactical Recommendations
Immunogenicity is a significant concern for biologic drugs as it can affect both safety and efficacy. To date, the descriptions of product immunogenicity have varied not only due to different degrees of unders...