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Article
Elevated Cellular Immune Response to Human Heat-Shock Protein-60 in Schizophrenic Patients
Heat shock protein-60 (HSP60) is implicated in several autoimmune diseases as a triggering antigen. Based on the autoimmune hypothesis of schizophrenia, we examined cellular and humoral responses against HSP6...
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Article
Human tumor cells, modified by a novel pressure/crosslinking methodology, promote autologous lymphocyte proliferation and modulate cytokine secretion
Hydrostatic pressure (P) combined with membrane protein crosslinking (CL) by adenosine dialdehyde (AdA) can render tumor cells immunogenic. We have recently shown that PCL treatment of murine tumor cells augm...
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Chapter
Tumor Vaccines — Perspectives and Practice
The immunological approach to cancer treatment and prevention is based on the notion that tumor cells bear antigens that can evoke the production of specific antibodies or more likely cytotoxic T-cells. Numero...
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Chapter
Membrane Fluidity and Receptor Function
Membrane processes can be grossly divided into those driven by metabolic energy (active processes) and those carried out through diffusion (passive processes). Most of the membranal active processes are associ...
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Article
Increase in lipid microviscosity of unilamellar vesicles upon the creation of transmembrane potential
Diffusion potential of potassium ions was formed in unilamellar vesicles of phosphatidyl choline. The vesicles, which included potassium sulfate buffered with potassium phosphate, were diluted into an analogou...
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Article
Insulin stimulation of glucose and amino acid transport in mouse fibroblasts with elevated membrane microviscosity
Basal and insulin-stimulated transport of 2-deoxy glucose and of α-aminoisobutyric acid in mouse 3T3 fibroblasts were modulated by increasing the lipid microviscosity of the cell plasma membrane. The kinetics ...
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Article
Positive skin tests with autologous tumor cells of increased membrane viscosity
Skin tests were carried out with irradiated autologous tumor cells in patients with solid tumors (large-bowel carcinoma, gastric carcinoma, malignant melanoma, and breast cancer). With untreated cells, the ski...
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Article
Induced drug release from lipid vesicles in serum by pH-change
Drugs can be released from lipid vesicles by pH-change in calf, horse or human serum when pH-sensitive trigger molecules are incorporated in the vesicle lipid bilayer. The lipid composition is so chosen that t...
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Article
Sphingomyelin phase transition in the sheep erythrocyte membrane
The dependence of membrane dynamics on the mole ratio of lecithin to sphingomyelin (L/S) was examined by the fluorescence depolarization of the fluidity probe DPH in membranes isolated from sheep and human ery...
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Article
Increased membrane fluidity precedes fusion of muscle cells
EMBRYONIC skeletal muscle cell cultures are highly suitable for demonstrating the dynamic role of the plasma membrane in cellular differentiation. A primary event in the overt development of muscle in culture ...
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Article
Increase in microviscosity with ageing in protoplast plasmalemma of rose petals
IT is now widely accepted that most physiological functions of biological membranes are related to the dynamic characteristics of transport, enzyme and receptor sites. Since the rotational and translational mo...
