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Article
Tailwater gravity currents and their connection to perfectly subcritical flow: laboratory experiments and shallow-water and direct numerical solutions
We report upon a series of laboratory experiments and complementary (two-dimensional) direct numerical simulations that explore the lock release of a fixed volume of dense fluid into a two-layer density-strati...
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Article
Integrin αvβ6 sets the stage for colorectal cancer metastasis
The β6 subunit of the αvβ6 integrin heterodimer has long been an enigma in cancer biology though recent research has provided many new insights into its biology. Collectively, these findings include discovery ...
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Article
Fetal growth restriction promotes physical inactivity and obesity in female mice
Environmental exposures during critical periods of prenatal and early postnatal life affect the development of mammalian body weight regulatory mechanisms, influencing lifelong risk of obesity. The specific bi...
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Article
Exercise and the neutrophil oxidative burst: biological and experimental variability
The effect of acute bouts of moderate-intensity running and cycling on the neutrophil oxidative burst was examined. Eight well-trained male runners in group 1 each undertook, on different days, either two 40-m...
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Article
Oxidation of articular cartilage glyceraldehyde-3-phosphate dehydrogenase (G3PDH) occurs in vivo during carrageenin-induced arthritis
Articular cartilage proteoglycan biosynthesis was substantially inhibited by the competitive glycolytic inhibitor 2-deoxyglucose (∼65% at 100 mM), but to a much lesser degree (∼10%) by the oxidative phosphorylati...