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  1. Article

    Open Access

    The new WHO 2022 and ICC proposals for the classification of myelodysplastic neoplasms. Validation based on the Düsseldorf MDS Registry and proposals for a merged classification

    K. Nachtkamp, C. Strupp, M. Vukelja, A. Kasprzak, D. Haase, C. Ganster… in Leukemia (2024)

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  2. Article

    Open Access

    Therapy-related myelodysplastic syndromes deserve specific diagnostic sub-classification and risk-stratification—an approach to classification of patients with t-MDS

    In the current World Health Organization (WHO)-classification, therapy-related myelodysplastic syndromes (t-MDS) are categorized together with therapy-related acute myeloid leukemia (AML) and t-myelodysplastic...

    A. Kuendgen, M. Nomdedeu, H. Tuechler, G. Garcia-Manero, R. S. Komrokji… in Leukemia (2021)

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  3. No Access

    Article

    Prognostic factors and follow-up parameters in patients with paroxysmal nocturnal hemoglobinuria (PNH): experience of the Austrian PNH network

    Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hematologic disease characterized by a deregulated complement system, chronic Coombs-negative, intravascular hemolysis, and a variable clinical course with s...

    Wolfgang Füreder, W. R. Sperr, S. Heibl, A. Zebisch… in Annals of Hematology (2020)

  4. No Access

    Article

    Validation of WHO classification-based Prognostic Scoring System (WPSS) for myelodysplastic syndromes and comparison with the revised International Prognostic Scoring System (IPSS-R). A study of the International Working Group for Prognosis in Myelodysplasia (IWG-PM)

    A risk-adapted treatment strategy is mandatory for myelodysplastic syndromes (MDS). We refined the World Health Organization (WHO)-classification-based Prognostic Scoring System (WPSS) by determining the impac...

    M G Della Porta, H Tuechler, L Malcovati, J Schanz, G Sanz, G Garcia-Manero… in Leukemia (2015)

  5. No Access

    Article

    Monosomal karyotype in MDS: explaining the poor prognosis?

    Monosomal karyotype (MK) is associated with an adverse prognosis in patients in acute myeloid leukemia (AML). This study analyzes the prognostic impact of MK in a cohort of primary, untreated patients with mye...

    J Schanz, H Tüchler, F Solé, M Mallo, E Luño, J Cervera, J Grau, B Hildebrandt… in Leukemia (2013)

  6. No Access

    Article

    Survival, prognostic factors and rates of leukemic transformation in 381 untreated patients with MDS and del(5q): A multicenter study

    Myelodysplastic syndromes (MDS) with del(5q) are considered to have a benign course of the disease. In order to address the issue of the propensity of those patients to progress to acute myeloid leukemia (AML)...

    U Germing, M Lauseker, B Hildebrandt, A Symeonidis, J Cermak, P Fenaux… in Leukemia (2012)

  7. No Access

    Article

    Myelodysplastic Syndromes (MDS) – News from ASH 2010

    In previous years ASH presentations regarding MDS focused on clinical trials in order to establish tailored treatment options for a significant number of patients. In contrast the main topics of the recent mee...

    T. Nösslinger, M. Pfeilstöcker in memo - Magazine of European Medical Oncology (2011)

  8. No Access

    Article

    Impact of adjunct cytogenetic abnormalities for prognostic stratification in patients with myelodysplastic syndrome and deletion 5q

    This cooperative study assessed prognostic factors for overall survival (OS) and risk of transformation to acute myeloid leukemia (AML) in 541 patients with de novo myelodysplastic syndrome (MDS) and deletion 5q....

    M Mallo, J Cervera, J Schanz, E Such, G García-Manero, E Luño, C Steidl… in Leukemia (2011)

  9. No Access

    Article

    Refinement of the international prognostic scoring system (IPSS) by including LDH as an additional prognostic variable to improve risk assessment in patients with primary myelodysplastic syndromes (MDS)

    The international prognostic scoring system (IPSS) is considered the gold standard for risk assessment in primary myelodysplastic syndromes (MDS). This score includes several prognostic factors except serum la...

    U Germing, B Hildebrandt, M Pfeilstöcker, T Nösslinger, P Valent, C Fonatsch… in Leukemia (2005)

  10. No Access

    Article

    Both IGH translocations and chromosome 13q deletions are early events in monoclonal gammopathy of undetermined significance and do not evolve during transition to multiple myeloma

    Molecular and genetic events associated with the transition from monoclonal gammopathy of undetermined significance (MGUS) to multiple myeloma (MM) are still poorly characterized. We investigated serial bone m...

    H Kaufmann, J Ackermann, C Baldia, T Nösslinger, R Wieser, S Seidl, V Sagaster… in Leukemia (2004)

  11. No Access

    Article

    In vivo and in vitro effects of cytokines and the hemoregulatory peptide dimer (pEEDCK)2 (pyroGlu-Glu-Asp-Cys-Lys)2 on Gα16-positive hematopoiesis

    G proteins play an important role in signal transduction from cytokine receptors to intracellular effectors via different pathways, eg involving tyrosine kinases. In our previous studies, we demonstrated that ...

    M Pfeilstöcker, H Karlic, J Paukovits, G Anzenberger, N Louda, J Salamon… in Leukemia (1999)

  12. No Access

    Article

    Monitoring of hematopoietic recovery after autologous stem cell transplantation by analysis of G alpha 16 mRNA and CD34 surface glycoprotein

     The hematopoiesis-specific G protein alpha subunit Gα16 was shown to be expressed in early normal and malignant hematopoietic cell lines and has been suggested to play an important role in signal transduction...

    M. Pfeilstöcker, H. Karlic, J. Salamon, H. Mühlberger, B. Pavlova… in Annals of Hematology (1998)

  13. No Access

    Chapter and Conference Paper

    CBFβ/MYH11 Rearrangement in M4Eo with Inversion 16: A Novel Marker for Diagnosis of Minimal Residual Disease by RT-PCR

    The inversion of chromosome 16(pl3-q22) is a characteristic cytogenetic marker for acute myelogenous leukemia subtype M4Eo. Recently the fusion gene product of this pericentric translocation was characterized....

    E. Koller, M. Pfeilstöcker, B. Pavlova, H. Mühlberger, H. Nowotny… in Acute Leukemias VI (1997)

  14. No Access

    Article

    Identification of leukaemic cells in bone marrow and blood samples by a new cytofluorometric assay

    The expression of thymidine kinase--an enzyme of the DNA precursor pathway--is strictly regulated during the normal cellular cycle, but is much higher and permanently expressed in malignant growing cells. We u...

    M Hengstschläger, M Pfeilstöcker, Edgar Wawra in British Journal of Cancer (1996)

  15. No Access

    Article

    FMS hemizygosity in myeloid dysplasia and acute myeloid leukemia with chromosomal aberration del(5)(q) demonstrated by polymerase chain reaction

    Interstitial deletions of the long arm of chromosome 5 del(5)(q), are recurring aberrations in the myelodysplastic syndrome and acute myeloid leukemia. Several genes located in region (5)(q23–34) have been imp...

    M. Pfeilstöcker, R. Grill, E. Koller, O. Krieger… in Journal of Molecular Medicine (1995)

  16. Article

    Abstract

    Ch. Mache, Ch. Urban, H. Sauer, G. Brandesky, H. Meßner… in Annals of Hematology (1992)

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