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Comparative evaluation of the novel IMMUNOCATCHTM Streptococcus pneumoniae (EIKEN CHEMICAL CO., LTD) test with the Uni-GoldTM Streptococcus pneumoniae assay and the BinaxNOW® Streptococcus pneumoniae antigen card for the detection of pneumococcal capsular antigen in urine samples
Community-acquired pneumonia (CAP) is one of the major causes of morbidity, mortality and hospitalization, and S. pneumoniae is the most frequently isolated etiologic agent. The pneumococcal urinary antigen test ...
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Multicenter performance evaluation of the Unyvero IAI cartridge for detection of intra-abdominal infections
Intra-abdominal infections (IAIs) are one of the most common type of infections in patients with sepsis and an important cause of death in intensive care units. Early detection and treatment are necessary to r...
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Open AccessThe BET inhibitor JQ1 selectively impairs tumour response to hypoxia and downregulates CA9 and angiogenesis in triple negative breast cancer
The availability of bromodomain and extra-terminal inhibitors (BETi) has enabled translational epigenetic studies in cancer. BET proteins regulate transcription by selectively recognizing acetylated lysine res...
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Erratum: Tumor hypoxia induces nuclear paraspeckle formation through HIF-2α dependent transcriptional activation of NEAT1 leading to cancer cell survival
Correction to: Oncogene advance online publication, 24 November 2014; doi:10.1038/onc.2014.378 Following the online publication of this article, the authors have noticed a misspelt surname: S Hider should read...
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Article
Open AccessTumor hypoxia induces nuclear paraspeckle formation through HIF-2α dependent transcriptional activation of NEAT1 leading to cancer cell survival
Activation of cellular transcriptional responses, mediated by hypoxia-inducible factor (HIF), is common in many types of cancer, and generally confers a poor prognosis. Known to induce many hundreds of protein...
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Murine α/β Interferons Inhibit Benzo(A)Pyrene Activation and Mutagenesis in Mice
In addition to their antiviral and immune regulatory properties, interferons (IFNs) are known to depress hepatic cytochrome P450-dependent metabolism. As many chemical mutagens and carcinogens require bioactiv...
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Chapter
The Direct-Acting Mutagenicity of Nitrothiophenes Derivatives in Salmonella Typhimurium
Nitroheterocyclic drugs have in recent years become of great interest for their mutagenicity and carcinogenicity. A series of nitrocompounds (structurally-related to the 5-nitro-3-thiophenecarboxylic acid) wer...