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  1. Article

    Open Access

    Oncolytic vaccinia virus as a vector for therapeutic sodium iodide symporter gene therapy in prostate cancer

    Oncolytic strains of vaccinia virus are currently in clinical development with clear evidence of safety and promising signs of efficacy. Addition of therapeutic genes to the viral genome may increase the thera...

    D C Mansfield, J N Kyula, N Rosenfelder, J Chao-Chu, G Kramer-Marek… in Gene Therapy (2016)

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    Article

    Synergistic cytotoxicity of oncolytic reovirus in combination with cisplatin–paclitaxel doublet chemotherapy

    Oncolytic reovirus is currently under active investigation in a range of tumour types. Early phase studies have shown that this agent has modest monotherapy efficacy and its future development is likely to foc...

    V Roulstone, K Twigger, S Zaidi, T Pencavel, J N Kyula, C White… in Gene Therapy (2013)

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    Article

    Genetic Background Influences UPR but not PLP Processing in the rumpshaker Model of PMD/SPG2

    Mutations of the proteolipid protein gene (PLP1) cause Pelizaeus-Merzbacher disease (PMD) and Spastic paraplegia type 2 (SPG2). The rumpshaker mutation is associated with mild forms of PMD or SPG2 in man and the ...

    M. McLaughlin, S. A. Karim, P. Montague, J. A. Barrie, D. Kirkham… in Neurochemical Research (2007)