55 Result(s)
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M. Mallar Chakravarty
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Open AccessEffects of diazepam on hippocampal blood flow in people at clinical high risk for psychosis
Elevated hippocampal perfusion has been observed in people at clinical high risk for psychosis (CHR-P). Preclinical evidence suggests that hippocampal hyperactivity is central to the pathophysiology of psychos...
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Longitudinal inference of multiscale markers in psychosis: from hippocampal centrality to functional outcome
Multiscale neuroscience conceptualizes mental illness as arising from aberrant interactions across and within multiple biopsychosocial scales. We leverage this framework to propose a multiscale disease progres...
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Open AccessPopulation-wide cerebellar growth models of children and adolescents
In the past, the cerebellum has been best known for its crucial role in motor function. However, increasingly more findings highlight the importance of cerebellar contributions in cognitive functions and neuro...
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Perception of social inclusion/exclusion and response inhibition in adolescents with past suicide attempt: a multidomain task-based fMRI study
The occurrence of suicidal behaviors increases during adolescence. Hypersensitivity to negative social signals and deficits in cognitive control are putative mechanisms of suicidal behaviors, which necessitate...
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Author Correction: A consensus protocol for functional connectivity analysis in the rat brain
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Open AccessCortical thinning in relation to impaired insight into illness in patients with treatment resistant schizophrenia
Impaired insight into illness is a common element of schizophrenia that contributes to treatment nonadherence and negative clinical outcomes. Previous studies suggest that impaired insight may arise from brain...
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A consensus protocol for functional connectivity analysis in the rat brain
Task-free functional connectivity in animal models provides an experimental framework to examine connectivity phenomena under controlled conditions and allows for comparisons with data modalities collected und...
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Open AccessOptimal deep brain stimulation sites and networks for stimulation of the fornix in Alzheimer’s disease
Deep brain stimulation (DBS) to the fornix is an investigational treatment for patients with mild Alzheimer’s Disease. Outcomes from randomized clinical trials have shown that cognitive function improved in so...
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Open AccessStress-inducible phosphoprotein 1 (HOP/STI1/STIP1) regulates the accumulation and toxicity of α-synuclein in vivo
The predominantly pre-synaptic intrinsically disordered protein α-synuclein is prone to misfolding and aggregation in synucleinopathies, such as Parkinson’s disease (PD) and Dementia with Lewy bodies (DLB). Mo...
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Open Accessneuromaps: structural and functional interpretation of brain maps
Imaging technologies are increasingly used to generate high-resolution reference maps of brain structure and function. Comparing experimentally generated maps to these reference maps facilitates cross-discipli...
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Open AccessIn Vivo 7-Tesla MRI Investigation of Brain Iron and Its Metabolic Correlates in Chronic Schizophrenia
Brain iron is central to dopaminergic neurotransmission, a key component in schizophrenia pathology. Iron can also generate oxidative stress, which is one proposed mechanism for gray matter volume reduction in...
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Open AccessMicrostructural imaging and transcriptomics of the basal forebrain in first-episode psychosis
Cholinergic dysfunction has been implicated in the pathophysiology of psychosis and psychiatric disorders such as schizophrenia, depression, and bipolar disorder. The basal forebrain (BF) cholinergic nuclei, d...
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Disruptions in white matter microstructure associated with impaired visual associative memory in schizophrenia-spectrum illness
Episodic memory ability relies on hippocampal-prefrontal connectivity. However, few studies have examined relationships between memory performance and white matter (WM) microstructure in hippocampal-prefrontal...
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Open AccessAltered amygdala shape trajectories and emotion recognition in youth at familial high risk of schizophrenia who develop psychosis
Relatives of individuals with schizophrenia have a higher risk of develo** the illness compared to the general population. Thus, youth at familial high risk (FHR) offer a unique opportunity to identify neuro...
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Early musical training shapes cortico-cerebellar structural covariation
Adult abilities in complex cognitive domains such as music appear to depend critically on the age at which training or experience begins, and relevant experience has greater long-term effects during periods of...
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Open AccessInvolvement of the habenula in the pathophysiology of autism spectrum disorder
The habenula is a small epithalamic structure with widespread connections to multiple cortical, subcortical and brainstem regions. It has been identified as the central structure modulating the reward value of...
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Open AccessAmyloid-beta modulates the association between neurofilament light chain and brain atrophy in Alzheimer’s disease
Neurofilament light chain (NFL) measurement has been gaining strong support as a clinically useful neuronal injury biomarker for various neurodegenerative conditions. However, in Alzheimer’s disease (AD), its ...
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Open AccessA systematic review of neuroimaging and acute cannabis exposure in age-of-risk for psychosis
Acute exposure to cannabis has been associated with an array of cognitive alterations, increased risk for neuropsychiatric illness, and other neuropsychiatric sequelae including the emergence of acute psychoti...
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Open AccessAudiovisual structural connectivity in musicians and non-musicians: a cortical thickness and diffusion tensor imaging study
Our sensory systems provide complementary information about the multimodal objects and events that are the target of perception in everyday life. Professional musicians’ specialization in the auditory domain i...
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Open AccessDeep learning identifies partially overlap** subnetworks in the human social brain
Complex social interplay is a defining property of the human species. In social neuroscience, many experiments have sought to first define and then locate ‘perspective taking’, ‘empathy’, and other psychologic...
