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Article
Open AccessSurface topography regulates wnt signaling through control of primary cilia structure in mesenchymal stem cells
The primary cilium regulates cellular signalling including influencing wnt sensitivity by sequestering β-catenin within the ciliary compartment. Topographic regulation of intracellular actin-myosin tension can...
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Article
Stent encrustation in feline and human artificial urine: does the low molecular weight composition account for the difference?
Anecdotal evidence suggests that the rate of encrustation on JJ stents placed in domesticated cats appears to be decreased as compared to humans. Our study tests the hypothesis that this may be due to specific...
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Article
Open AccessPrimary cilia elongation in response to interleukin-1 mediates the inflammatory response
Primary cilia are singular, cytoskeletal organelles present in the majority of mammalian cell types where they function as coordinating centres for mechanotransduction, Wnt and hedgehog signalling. The length ...
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Chapter and Conference Paper
Finite Element Modeling of Cell Deformation When Chondrocyte Seeded Agarose Is Subjected to Compression
Dynamic loading is known to be essential in the biosynthesis and maintenance of healthy matabolism in articular cartilage and chondrocyte-seeded hydrogels. This is thought to be a result of a range of factors,...
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Article
Open AccessBiomechanical analysis of structural deformation in living cells
Most tissues are subject to some form of physiological mechanical loading which results in deformation of the cells triggering intracellular mechanotransduction pathways. This response to loading is generally ...
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Article
Chondrocyte Deformation Induces Mitochondrial Distortion and Heterogeneous Intracellular Strain Fields
Chondrocyte mechanotransduction is poorly understood but may involve cell deformation and associated distortion of intracellular structures and organelles. This study quantifies the intracellular displacement ...
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Article
The analysis of fatty alcohols and acids asp-(methylthio)-benzoate esters
Thep-(methylthio)-benzoate ester of fatty alcohols is investigated. This derivative shows either a molecular ion or M-168 m/e peak in its mass spectrum and mixtures may be qualitatively analyzed directly by mass ...
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Article
Aggregation response of nymphs to pheromone(s) produced by males of the tick Amblyomma hebraeum (Koch)
No aggregation response by tick nymphs to a pheromone(s) produced by males had been described, although such a response had been demonstrated in adults1–8. We have now shown that males of the hard tick Amblyomma ...
