Intelligent Systems'2014
Proceedings of the 7th IEEE International Conference Intelligent Systems IS’2014, September 24‐26, 2014, Warsaw, Poland, Volume 2: Tools, Architectures, Systems, Applications
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Article
Open AccessLong-term health sequelae and quality of life at least 6 months after infection with SARS-CoV-2: design and rationale of the COVIDOM-study as part of the NAPKON population-based cohort platform (POP)
Over the course of COVID-19 pandemic, evidence has accumulated that SARS-CoV-2 infections may affect multiple organs and have serious clinical sequelae, but on-site clinical examinations with non-hospitalized ...
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Article
Serum metabolomic profiling highlights pathways associated with liver fat content in a general population sample
Fatty liver disease (FLD) is an important intermediate trait along the cardiometabolic disease spectrum and strongly associates with type 2 diabetes. Knowledge of biological pathways implicated in FLD is limit...
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Article
Open AccessFive years of experience with the FiLaC™ laser for fistula-in-ano management: long-term follow-up from a single institution
There are limited data available concerning endofistular therapies for fistula-in-ano, with our group reporting the first preliminary outcomes of the use of the radial fibre Fistula laser Closing (FiLaC ™) de...
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Book and Conference Proceedings
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Article
Next Generation Sequencing in der diagnostischen Praxis
Next Generation Sequencing (NGS) erlaubt die Untersuchung des kompletten Exoms oder Genoms eines Patienten mit vertretbarem zeitlichem und finanziellem Aufwand. Dieser diagnostische Quantensprung hat neben rec...
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Article
Archivierung von Genomdaten
Angesichts der zunehmenden Datenflut in der Genomforschung wird ein effizientes Forschungsdatenmanagement, verbunden mit einer sicheren und nachhaltigen Archivierung, auch in diesem Wissenschaftsbereich immer ...
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Article
Ethische und rechtliche Implikationen der Speicherung humaner Genomdaten
Die Entwicklung der DNA-Sequenzierungstechnologien stellt die humane Genomforschung vor große datenschutzrechtliche und ethische Herausforderungen. Der heute bereits mögliche tiefe Einblick in die genetische A...
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Article
PopGen
Die Biobank PopGen wurde 2003 zur Erforschung genetischer Risikofaktoren für komplexe Humanerkrankungen etabliert. Neben Daten betroffener Patienten umfasst sie auch solche zufällig ausgewählter Personen aus d...
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Article
Examination of the current top candidate genes for AD in a genome-wide association study
With the advent of technologies that allow simultaneous genoty** of thousands of single-nucleotide polymorphisms (SNPs) across the genome, the genetic contributions to complex diseases can be explored at an ...
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Chapter
Generalized Net Model for Parallel Optimization of Feed-Forward Neural Network with Variable Learning Rate Backpropagation Algorithm with Time Limit
The used generalized net will give us a possibility for parallel optimization of a feed-forward neural network based on assigned training pairs with variable learning rate backpropagation algorithm with time l...
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Chapter
Towards a Model of the Digital University: A Generalized Net Model for Producing Course Timetables and for Evaluating the Quality of Subjects
In a series of research papers, the authors study some of the most important processes of functioning of universities and construct their Generalized Net (GN) models. The main focus in this paper is to analyse...
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Chapter and Conference Paper
Genomweite Untersuchung identifiziert den hepatischen Cholesterol Transporter ABCG8 als Suszeptibilitäts-Faktor für das humane Gallensteinleiden
Gallstone disease is a common disorder with a prevalence of approximately 20 % in industrialized countries. We performed a genome-wide disease association scan of over 500,000 single nucleotide polymorphisms (...
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Article
Mhc class I haplotypes associated with survival time in simian immunodeficiency virus (SIV)-infected rhesus macaques
In both human immunodeficiency virus-infected humans and simian immunodeficiency virus (SIV)-infected macaques, genes encoded in the major histocompatibility complex (MHC) class I region are important determin...
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Article
Modellvorstellungen zur Genetik multifaktorieller Krankheiten
Im Gegensatz zu monogenen Erkrankungen kann bei multifaktoriellen genetisch bedingten Krankheiten aufgrund der Vielzahl genetischer und nichtgenetischer Faktoren keine klare Genotyp-Phänotyp-Beziehung erwartet...
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Article
Common familial influences on clustering of metabolic syndrome traits with central obesity and insulin resistance: the Kiel obesity prevention study
The phenotypic heterogeneity of metabolic syndrome (MSX) suggests heterogeneity of the underlying genotype. The aim of the present study was to examine the common genetic background that contributes to the clu...
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Article
Correction: Corrigendum: Sarcoidosis is associated with a truncating splice site mutation in the gene BTNL2
Nat. Genet. 37, 357–364 (2005). In the version of Supplementary Table 3 initially published online, the nomenclature of DQB and DPB alleles was partly incorrect. The errors have now been corrected and Suppleme...
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Article
Use of X-linked markers for forensic purposes
In forensic science, X-chromosomal short tandem repeats (ChrX STRs) bear the potential to efficiently complement the analysis of other genetic markers (autosomal, Y-chromosomal or mitochondrial). We review the...
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Article
Linkage disequilibrium map** provides further evidence of a gene for reading disability on chromosome 6p21.3–22
Linkage disequilibrium (LD) map** was used to follow up reports of linkage between reading disability (RD) and an 18 cM region of chromosome 6p21.3–22. Using a two-stage approach, we tested for association b...
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Article
Mutation screening and LD map** in the VCFS deleted region of chromosome 22q11 in schizophrenia using a novel DNA pooling approach
We examined whether variation within six genes from the VCFS critical region at 22q11 (DGSC, Stk22A1, DGSI, Gscl, Slc25A1 and Znf74) confers susceptibility to schizophrenia. We screened the exons and flanking int...
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Article
Pharmacogenetic investigation of the TNF/TNF-receptor system in patients with chronic active Crohn's disease treated with infliximab
Infliximab (anti-TNF-α monoclonal antibody) induces remission in 30–40% of Crohn's disease patients. Treatment response is a stable trait. Two cohorts from independent, prospective clinical trials of inflixima...
