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  1. Article

    Open Access

    Individual caspase-10 isoforms play distinct and opposing roles in the initiation of death receptor-mediated tumour cell apoptosis

    The cysteine protease caspase-8 is an essential executioner of the death receptor (DR) apoptotic pathway. The physiological function of its homologue caspase-10 remains poorly understood, and the ability of ca...

    A Mühlethaler-Mottet, M Flahaut, K Balmas Bourloud, K Nardou… in Cell Death & Disease (2011)

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    Article

    The Wnt receptor FZD1 mediates chemoresistance in neuroblastoma through activation of the Wnt/β-catenin pathway

    The development of chemoresistance represents a major obstacle in the successful treatment of cancers such as neuroblastoma (NB), a particularly aggressive childhood solid tumour. The mechanisms underlying the...

    M Flahaut, R Meier, A Coulon, K A Nardou, F K Niggli, D Martinet, J S Beckmann… in Oncogene (2009)

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    Article

    Persistent inhibition of FLIPL expression by lentiviral small hairpin RNA delivery restores death-receptor-induced apoptosis in neuroblastoma cells

    Neuroblastoma represents the most common and deadly solid tumour of childhood, which disparate biological and clinical behaviour can be explained by differential regulation of apoptosis. To understand mechanis...

    M. Flahaut, A. Mühlethaler-Mottet, K. Auderset, K. Balmas Bourloud, R. Meier… in Apoptosis (2006)