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  1. Article

    PH domain leucine-rich repeat protein phosphatase 1 contributes to maintain the activation of the PI3K/Akt pro-survival pathway in Huntington's disease striatum

    Dysregulation of gene expression is one of the mechanisms involved in the pathophysiology of Huntington's disease (HD). Here, we examined whether mutant huntingtin regulates the levels of PH domain leucine-ric...

    A Saavedra, J M García-Martínez, X **fró, A Giralt… in Cell Death & Differentiation (2010)

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    Is the ubiquitin-proteasome system impaired in Huntington’s disease?

    Ubiquitylated inclusion bodies (IBs) found in Huntington’s disease (HD) postulate an impaired ubiquitin-proteasome system. However, this hypothesis remains controversial. In vitro-generated polyglutamine aggregat...

    Z. Ortega, M. Díaz-Hernández, J. J. Lucas in Cellular and Molecular Life Sciences (2007)

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    Role of CaCMKII in the cross talk between lonotropic nucleotide and nicotinic receptors in individual cholinergic terminals

    M. Díaz-Hernández, J. Sánchez-Nogueiro… in Journal of Molecular Neuroscience (2006)