Skip to main content

7 Result(s)

within M. Chillón Remove this filter

and

  1. Article

    Open Access

    Secreted αKlotho isoform protects against age-dependent memory deficits

    αKlotho is a gene regulator of aging, increasing life expectancy when overexpressed and accelerating the development of aging phenotypes when inhibited. In mice, expression levels of the secreted isoform Klotho (...

    A Massó, A Sánchez, A Bosch, L Giménez-Llort, M Chillón in Molecular Psychiatry (2018)

    Download PDF (5140 KB) View Article

  2. No Access

    Article

    AAVrh.10 immunogenicity in mice and humans. Relevance of antibody cross-reactivity in human gene therapy

    Simian adeno-associated virus (AAV) serotype rh.10 is a promising gene therapy tool, achieving safe, sustained transgene expression in the nervous system, lung, liver and heart in animal models. To date, preex...

    R Thwaite, G Pagès, M Chillón, A Bosch in Gene Therapy (2015)

  3. No Access

    Article

    Schwann cell targeting via intrasciatic injection of AAV8 as gene therapy strategy for peripheral nerve regeneration

    Efficient transduction of the peripheral nervous system (PNS) is required for gene therapy of acquired and inherited neuropathies, neuromuscular diseases and for pain treatment. We have characterized the tropi...

    J Homs, L Ariza, G Pagès, E Udina, X Navarro, M Chillón, A Bosch in Gene Therapy (2011)

  4. No Access

    Article

    Adenovirus complexed with polyethylene glycol and cationic lipid is shielded from neutralizing antibodies in vitro

    Development of neutralizing antibodies is an important hindrance that limits repeated administration of adenoviral vectors for gene transfer. One way to avoid this problem would be to coat the virus with a sub...

    M Chillón, JH Lee, A Fasbender, MJ Welsh in Gene Therapy (1998)

  5. No Access

    Article

    Extensive analysis of 40 infertile patients with congenital absence of the vas deferens: in 50% of cases only one CFTR allele could be detected

    Mutations in the cystic fibrosis (CF) conductance transmembrane regulator (CFTR) gene have been detected in patients with CF and in males with infertility attributable to congenital bilateral absence of the va...

    T. Casals, L. Bassas, J. Ruiz-Romero, M. Chillón, J. Giménez, M. D. Ramos… in Human Genetics (1995)

  6. No Access

    Article

    A rare DNA variant in exon 15 of the cystic fibrosis transmembrane conductance regulator (CFTR) gene

    We describe a rare single-strand conformation polymorphism that occurs at nucleotide 3030 (G or A) in exon 15 of the cystic fibrosis transmembrane conductance regulator gene.

    M. Chillón, A. Palacio, V. Nunes, X. Estivill in Human Genetics (1992)

  7. No Access

    Article

    Distribution of the ΔF508 mutation in 194 Spanish cystic fibrosis families

    Spanish cystic fibrosis (CF) families (n = 194) have been analysed for the ΔF508 mutation, and for closely linked DNA markers. The ΔF508 mutation accounts for 50% of CF chromosomes. Four haplotypes are associated...

    M. Chillón, V. Nunes, T. Casals, F. J. Giménez, E. Fernández, J. Benítez… in Human Genetics (1990)