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Article
The Smart Library Architecture of an Orientation Portal
The high potential for synergies between Knowledge Management (KM) and e-Learning seems obvious given the many interrelations and dependencies of these two fields. However, the relationship has not yet been fu...
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Article
Interleukin-1β inhibition of insulin release in rat pancreatic islets: Possible involvement of G-proteins in the signal transduction pathway
In vitro exposure of rat pancreatic beta cells to interleukin-1β (IL-lβ) inhibits glucose-stimulated insulin release (2140 α 239 and 323±80 pg · islet-1 · h-1 at glucose levels of 16.7 mmol/l in control and IL-l ...
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Article
Copper addition prevents the inhibitory effects of interleukin 1-β on rat pancreatic islets
Since copper [Cu(II)] is a necessary cofactor for both intra-mitochondrial enzymes involved in energy production and hydroxyl scavenger enzymes, two hypothesised mechanisms for action of interleukin-Iβ (IL-1β)...
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Article
Inhibition of the high-affinity glucose transporter GLUT 1 affects the sensitivity to glucose in a hamster-derived pancreatic beta cell line (HIT)
HIT is a hamster-derived beta-cell line which in contrast to normal beta cells that only express the high Km GLUT-2 glucose transporter, also expresses the low Km glucose transporter GLUT 1. In HIT cells the abno...
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Article
Different effects of glucose and glyburide on insulin secretion in rat pancreatic islets pre-exposed to interleukin-1β. Possible involvement of K+ and Ca2+ channels
In vitro islet exposure to interleukin 1β inhibits the beta-cell response to glucose. We have studied whether a similar inhibition also occurs in response to the sulphonylurea glyburide. Rat pancreatic islets wer...
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Article
Glucose regulates both glucose transport and the glucose transporter gene expression in a hamster-derived pancreatic Beta-cell line (HIT)
We studied the effect of chronic exposure to high glucose on the glucose transport regulation in hamster pancreatic Beta cells in permanent culture (HIT). Cells were exposed to either 5.5 mmol/l or 16.7 mmol/l...
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Article
Chronic exposure to glibenclamide impairs insulin secretion in isolated rat pancreatic islets
We investigated the effect of 24 h exposure to 100 nmol/l glibenclamide on insulin secretion in isolated rat pancreatic islets. The insulin content was similar in control islets and in islets preincubated with...
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Article
Neuere Aspekte zur Pathogenese endokriner Autoimmunerkrankungen des Menschen: Welche Rolle spielt die Expression von HLA Klasse-II-Molekülen durch die endokrine Zielzelle?
The inappropriate expression of HLA Class II molecules by the target cells of endocrine autoimmune diseases is a recent observation that has been intensively studied in thyroid autoimmunity and type I diabetes...
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Article
Metformin enhances certain insulin actions in cultured rat hepatoma cells
The effect of the oral antidiabetic agent metformin on insulin regulation of glycogen metabolism, tyrosine-aminotransferase activity, and [1-14C]aminoisobutyric acid uptake was studied in H4IIE cultured rat hepat...
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Article
Isolation of a highly pure archeocyte fraction from the fresh-water spongeEphydatia fluviatilis
A pure archeocyte fraction was isolated from the fresh-water spongeEphydatia fluviatilis by density gradient centrifugation of dissociated cell suspensions. The nature and purity of the fraction were confirmed by...
