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  1. No Access

    Article

    Factors influencing catheter-related infections in the Dutch multicenter study on high-dose chemotherapy followed by peripheral SCT in high-risk breast cancer patients

    Neutropenia following high-dose chemotherapy leads to a high incidence of infectious complications, of which central venous catheter-related infections predominate. Catheter-related infections and associated r...

    P Nieboer, E G E de Vries, N H Mulder, S Rodenhuis… in Bone Marrow Transplantation (2008)

  2. Article

    Open Access

    Molecular subtypes of breast cancer and amplification of topoisomerase IIα: predictive role in dose intensive adjuvant chemotherapy

    Benefit from chemotherapy treatment in breast cancer patients is determined by the molecular make-up of the tumour. In a retrospective analysis, we determined the molecular subtypes of breast cancer originally...

    J Hannemann, P Kristel, H van Tinteren, M Bontenbal… in British Journal of Cancer (2006)

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  3. Article

    Efficacy of high-dose alkylating chemotherapy in the adjuvant treatment of HER2/neu-negative primary breast cancer: update of the Dutch randomized trial

    S Rodenhuis, M Bontenbal, LVAM Beex, WM Smit, MA Nooij, EE Voest… in Breast Cancer Research (2005)

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  4. No Access

    Article

    Phase II study of weekly gemcitabine in patients with metastatic breast cancer relapsing or failing both an anthracycline and a taxane

    A phase II study was performed to investigate the efficacy and tolerability of gemcitabine as third-line chemotherapy for patients with metastatic breast cancer, previously treated with both an anthracycline -...

    C.H. Smorenburg, M. Bontenbal, C. Seynaeve… in Breast Cancer Research and Treatment (2001)

  5. No Access

    Article

    Doxorubicin vs epirubicin, report of a second-line randomized phase II/III study in advanced breast cancer

    The EORTC Breast Cancer Cooperative Group carried out a randomized trial to compare doxorubicin with epirubicin as second-line chemotherapy in patients with metastatic breast cancer. Two hundred and fifty-nine...

    M Bontenbal, M Andersson, J Wildiers, G Cocconi, J Jassem… in British Journal of Cancer (1998)

  6. No Access

    Article

    Feasibility, endocrine and anti-tumour effects of a triple endocrine therapy with tamoxifen, a somatostatin analogue and an antiprolactin in post-menopausal metastatic breast cancer: a randomized study with long-term follow-up

    Suppression of the secretion of prolactin, growth hormone and insulin-like growth factor 1 (IGF-1) might be important in the growth regulation and treatment of breast cancer. Because oestrogens may counteract ...

    M Bontenbal, JA Foekens, SWJ Lamberts, FH de Jong… in British Journal of Cancer (1998)

  7. No Access

    Article

    MRI in patients with axillary metastases of occult breast carcinoma

    In 4 women with adenocarcinoma metastasis in anaxillary lymph node and no primary tumor found,we investigated whether Magnetic Resonance Imaging (MRI) ofthe breast could detect a clinically and mammographicall...

    M.M.A. Tilanus-Linthorst, A.I.M. Obdeijn… in Breast Cancer Research and Treatment (1997)

  8. No Access

    Article

    Phase II study of intensive chemotherapy with autologous bone marrow transplantation in patients in complete remission of disseminated breast cancer

    This trial studied the disease-free survival after high-dose chemotherapy in patients in complete remission of metastatic breast cancer.

    E. G. E. de Vries, S. Rodenhuis, H. C. Schouten… in Breast Cancer Research and Treatment (1996)

  9. No Access

    Article

    Second-line chemotherapy with long-term low-dose oral etoposide in patients with advanced breast cancer

    In a phase II study, 27 patients with metastatic breast cancer were treated with oral etoposide as second-line chemotherapy at a dose of 50 mg/m2/day for 21 days, which courses were repeated every 4 weeks. Twenty...

    M. Bontenbal, A. S. Th. Planting, J. Verweij… in Breast Cancer Research and Treatment (1995)

  10. No Access

    Article

    Relationship of PS2 with response to tamoxifen therapy in patients with recurrent breast cancer

    PS2, an oestrogen-inducible protein, was measured in the cytosol of 230 primary tumours from patients who were subjected to first-line tamoxifen therapy for advanced disease without prior adjuvant therapy with...

    JA Foekens, H Portengen, MP Look, WLJ van Putten, B Thirion… in British Journal of Cancer (1994)

  11. No Access

    Chapter and Conference Paper

    Critical Review of Growth Factors as Clinical Tools in Primary and Metastatic Breast Cancer

    Present research in the field of clinical breast cancer is focused on new diagnostic methods and on the development of new treatment modalities [25]. Adjuvant systemic therapy with chemotherapeutic drugs or en...

    J. G. M. Klijn, P. M. J. J. Berns… in Adjuvant Therapy of Breast Cancer IV (1993)

  12. No Access

    Article

    Weekly low-dose mitoxantrone plus doxorubicin as second-line chemotherapy for advanced breast cancer

    Weekly low dose mitoxantrone (3 mg/m2) plus doxorubicin (8 mg/m2) was administered as second-line chemotherapy to 33 patients with advanced breast cancer. Four out of 28 evaluable patients (14%) obtained a partia...

    M. Bontenbal, A. S. Th. Planting, C. J. Rodenburg… in Breast Cancer Research and Treatment (1992)

  13. No Access

    Chapter

    New Diagnostic Methods and Treatment Modalities in Breast Cancer

    Present research in the field of clinical breast cancer is focussed on new diagnostic methods and on the development of new treatment modalities. A number of modern cell biological parameters such as oncogenes...

    J. G. M. Klijn, P. M. J. J. Berns… in Breast Cancer: Biological and Clinical Pro… (1992)

  14. No Access

    Article

    Effect of hormonal manipulation and doxorubicin administration on cell cycle kinetics of human breast cancer cells

    Dual-parameter flow cytometry, following bromodeoxyuridine (BrdUrd) incorporation and propidium iodide (PI) uptake into DNA, was used to study the effects of oestradiol and/or insulin on cell cycle kinetics of...

    M Bontenbal, AM Sieuwerts, JGM Klijn, HA Peters, HLJM Krijnen… in British Journal of Cancer (1989)