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Article
Factors influencing catheter-related infections in the Dutch multicenter study on high-dose chemotherapy followed by peripheral SCT in high-risk breast cancer patients
Neutropenia following high-dose chemotherapy leads to a high incidence of infectious complications, of which central venous catheter-related infections predominate. Catheter-related infections and associated r...
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Article
Open AccessMolecular subtypes of breast cancer and amplification of topoisomerase IIα: predictive role in dose intensive adjuvant chemotherapy
Benefit from chemotherapy treatment in breast cancer patients is determined by the molecular make-up of the tumour. In a retrospective analysis, we determined the molecular subtypes of breast cancer originally...
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Article
Efficacy of high-dose alkylating chemotherapy in the adjuvant treatment of HER2/neu-negative primary breast cancer: update of the Dutch randomized trial
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Article
Phase II study of weekly gemcitabine in patients with metastatic breast cancer relapsing or failing both an anthracycline and a taxane
A phase II study was performed to investigate the efficacy and tolerability of gemcitabine as third-line chemotherapy for patients with metastatic breast cancer, previously treated with both an anthracycline -...
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Article
Doxorubicin vs epirubicin, report of a second-line randomized phase II/III study in advanced breast cancer
The EORTC Breast Cancer Cooperative Group carried out a randomized trial to compare doxorubicin with epirubicin as second-line chemotherapy in patients with metastatic breast cancer. Two hundred and fifty-nine...
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Article
Feasibility, endocrine and anti-tumour effects of a triple endocrine therapy with tamoxifen, a somatostatin analogue and an antiprolactin in post-menopausal metastatic breast cancer: a randomized study with long-term follow-up
Suppression of the secretion of prolactin, growth hormone and insulin-like growth factor 1 (IGF-1) might be important in the growth regulation and treatment of breast cancer. Because oestrogens may counteract ...
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Article
MRI in patients with axillary metastases of occult breast carcinoma
In 4 women with adenocarcinoma metastasis in anaxillary lymph node and no primary tumor found,we investigated whether Magnetic Resonance Imaging (MRI) ofthe breast could detect a clinically and mammographicall...
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Article
Phase II study of intensive chemotherapy with autologous bone marrow transplantation in patients in complete remission of disseminated breast cancer
This trial studied the disease-free survival after high-dose chemotherapy in patients in complete remission of metastatic breast cancer.
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Article
Second-line chemotherapy with long-term low-dose oral etoposide in patients with advanced breast cancer
In a phase II study, 27 patients with metastatic breast cancer were treated with oral etoposide as second-line chemotherapy at a dose of 50 mg/m2/day for 21 days, which courses were repeated every 4 weeks. Twenty...
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Article
Relationship of PS2 with response to tamoxifen therapy in patients with recurrent breast cancer
PS2, an oestrogen-inducible protein, was measured in the cytosol of 230 primary tumours from patients who were subjected to first-line tamoxifen therapy for advanced disease without prior adjuvant therapy with...
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Chapter and Conference Paper
Critical Review of Growth Factors as Clinical Tools in Primary and Metastatic Breast Cancer
Present research in the field of clinical breast cancer is focused on new diagnostic methods and on the development of new treatment modalities [25]. Adjuvant systemic therapy with chemotherapeutic drugs or en...
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Article
Weekly low-dose mitoxantrone plus doxorubicin as second-line chemotherapy for advanced breast cancer
Weekly low dose mitoxantrone (3 mg/m2) plus doxorubicin (8 mg/m2) was administered as second-line chemotherapy to 33 patients with advanced breast cancer. Four out of 28 evaluable patients (14%) obtained a partia...
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Chapter
New Diagnostic Methods and Treatment Modalities in Breast Cancer
Present research in the field of clinical breast cancer is focussed on new diagnostic methods and on the development of new treatment modalities. A number of modern cell biological parameters such as oncogenes...
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Article
Effect of hormonal manipulation and doxorubicin administration on cell cycle kinetics of human breast cancer cells
Dual-parameter flow cytometry, following bromodeoxyuridine (BrdUrd) incorporation and propidium iodide (PI) uptake into DNA, was used to study the effects of oestradiol and/or insulin on cell cycle kinetics of...