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M. **gliang
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Open AccessA bipolar disorder-associated missense variant alters adenylyl cyclase 2 activity and promotes mania-like behavior
The single nucleotide polymorphism rs13166360, causing a substitution of valine (Val) 147 to leucine (Leu) in the adenylyl cyclase 2 (ADCY2), has previously been associated with bipolar disorder (BD). Here we ...
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Open AccessGermline β−1,3-glucan deposits are required for female gametogenesis in Arabidopsis thaliana
Correct regulation of intercellular communication is a fundamental requirement for cell differentiation. In Arabidopsis thaliana, the female germline differentiates from a single somatic ovule cell that becomes e...
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Open AccessGenetic and multi-omic resources for Alzheimer disease and related dementia from the Knight Alzheimer Disease Research Center
The Knight-Alzheimer Disease Research Center (Knight-ADRC) at Washington University in St. Louis has pioneered and led worldwide seminal studies that have expanded our clinical, social, pathological, and molec...
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Open AccessDefinitive engineering strength and fracture toughness of graphene through on-chip nanomechanics
Fail-safe design of devices requires robust integrity assessment procedures which are still absent for 2D materials, hence affecting transfer to applications. Here, a combined on-chip tension and cracking meth...
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Open AccessSearch for the \( {B}_s^0 \) → μ+μ−γ decay
A search for the fully reconstructed B s 0 ...
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Open AccessFormative research to understand food beliefs and practices relating to pregnancy on Kei Besar Island, Eastern Indonesia
Food-related beliefs and practices during pregnancy may contribute to the high prevalence of chronic energy deficiencies (CED) in Eastern Indonesia, particularly in Southeast Maluku regency, where 21.33% of pr...
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Open AccessHealth and wellbeing of staff working at higher education institutions globally during the post-COVID-19 pandemic period: evidence from a cross-sectional study
The ongoing global crisis of Higher Education (HE) institutions during the post-COVID-19 pandemic period has increased the likelihood of enduring psychological stressors for staff. This study aimed to identify...
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Open AccessEngineering hyaluronic acid-based nanoassemblies for monoclonal antibody delivery – design, characterization, and biological insights
The current spotlight of cancer therapeutics is shifting towards personalized medicine with the widespread use of monoclonal antibodies (mAbs). Despite their increasing potential, mAbs have an intrinsic limita...
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Open AccessSex-specific alterations in functional connectivity and network topology in patients with degenerative cervical myelopathy
Patients with degenerative cervical myelopathy (DCM) experience structural and functional brain reorganization. However, few studies have investigated the influence of sex on cerebral alterations. The present ...
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Open AccessSingle cell transcriptomes and multiscale networks from persons with and without Alzheimer’s disease
The emergence of single nucleus RNA sequencing (snRNA-seq) offers to revolutionize the study of Alzheimer’s disease (AD). Integration with complementary multiomics data such as genetics, proteomics and clinica...
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Open AccessA benchmark JWST near-infrared spectrum for the exoplanet WASP-39 b
Observing exoplanets through transmission spectroscopy supplies detailed information about their atmospheric composition, physics and chemistry. Before the James Webb Space Telescope (JWST), these observations...
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Open AccessEfficacy and safety of oral semaglutide vs sitagliptin in a predominantly Chinese population with type 2 diabetes uncontrolled with metformin: PIONEER 12, a double-blind, Phase IIIa, randomised trial
The aim of this study was to assess the efficacy and safety of oral semaglutide vs sitagliptin in a predominantly Chinese population with type 2 diabetes inadequately controlled with metformin treatment.
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Open AccessAirborne DNA reveals predictable spatial and seasonal dynamics of fungi
Fungi are among the most diverse and ecologically important kingdoms in life. However, the distributional ranges of fungi remain largely unknown as do the ecological mechanisms that shape their distributions1,2. ...
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Open AccessAssessment of factors and mechanism contributing to groundwater depressurisation due to longwall mining
Assessment of mining impact on groundwater is one of critical considerations for longwall extension and sustainability, however usually constrained by limited data availability, hydrogeological variation, and ...
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Open AccessEngineering phase competition between stripe order and superconductivity in La1.88Sr0.12CuO4
Unconventional superconductivity often couples to other electronic orders in a cooperative or competing fashion. Identifying external stimuli that tune between these two limits is of fundamental interest. Here...
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Open AccessFAM122A ensures cell cycle interphase progression and checkpoint control by inhibiting B55α/PP2A through helical motifs
The Ser/Thr protein phosphatase 2 A (PP2A) regulates the dephosphorylation of many phosphoproteins. Substrate recognition are mediated by B regulatory subunits. Here, we report the identification of a substrat...
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Open AccessHigh Temperature Corrosion Resistant and Anti-slagging Coatings for Boilers: A Review
High temperature corrosion and slag deposition significantly reduce the thermal efficiency and lifespan of biomass-fired boilers. Surface modification with protective coatings can enhance boiler performance an...
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Open Access“Textbook outcome(s)” in colorectal surgery: a systematic review and meta-analysis
Textbook outcome (TO) is a composite measure used in surgery to evaluate post operative outcomes. No review has synthesised the evidence in relation to TO regarding the elements surgeons are utilising to infor...
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Open AccessSparse transformer with local and seasonal adaptation for multivariate time series forecasting
Transformers have achieved remarkable performance in multivariate time series(MTS) forecasting due to their capability to capture long-term dependencies. However, the canonical attention mechanism has two key ...
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Open AccessIdentification of Parkinson’s disease PACE subtypes and repurposing treatments through integrative analyses of multimodal data
Parkinson’s disease (PD) is a serious neurodegenerative disorder marked by significant clinical and progression heterogeneity. This study aimed at addressing heterogeneity of PD through integrative analysis of...
