2,964 Result(s)
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M. **gliang
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessGermline β−1,3-glucan deposits are required for female gametogenesis in Arabidopsis thaliana
Correct regulation of intercellular communication is a fundamental requirement for cell differentiation. In Arabidopsis thaliana, the female germline differentiates from a single somatic ovule cell that becomes e...
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Open AccessGenetic and multi-omic resources for Alzheimer disease and related dementia from the Knight Alzheimer Disease Research Center
The Knight-Alzheimer Disease Research Center (Knight-ADRC) at Washington University in St. Louis has pioneered and led worldwide seminal studies that have expanded our clinical, social, pathological, and molec...
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Open AccessDefinitive engineering strength and fracture toughness of graphene through on-chip nanomechanics
Fail-safe design of devices requires robust integrity assessment procedures which are still absent for 2D materials, hence affecting transfer to applications. Here, a combined on-chip tension and cracking meth...
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Open AccessSex-specific alterations in functional connectivity and network topology in patients with degenerative cervical myelopathy
Patients with degenerative cervical myelopathy (DCM) experience structural and functional brain reorganization. However, few studies have investigated the influence of sex on cerebral alterations. The present ...
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Open AccessSingle cell transcriptomes and multiscale networks from persons with and without Alzheimer’s disease
The emergence of single nucleus RNA sequencing (snRNA-seq) offers to revolutionize the study of Alzheimer’s disease (AD). Integration with complementary multiomics data such as genetics, proteomics and clinica...
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Open AccessAirborne DNA reveals predictable spatial and seasonal dynamics of fungi
Fungi are among the most diverse and ecologically important kingdoms in life. However, the distributional ranges of fungi remain largely unknown as do the ecological mechanisms that shape their distributions1,2. ...
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Open AccessFAM122A ensures cell cycle interphase progression and checkpoint control by inhibiting B55α/PP2A through helical motifs
The Ser/Thr protein phosphatase 2 A (PP2A) regulates the dephosphorylation of many phosphoproteins. Substrate recognition are mediated by B regulatory subunits. Here, we report the identification of a substrat...
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Open AccessSparse transformer with local and seasonal adaptation for multivariate time series forecasting
Transformers have achieved remarkable performance in multivariate time series(MTS) forecasting due to their capability to capture long-term dependencies. However, the canonical attention mechanism has two key ...
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Open AccessExtremozymes and compatible solute production potential of halophilic and halotolerant bacteria isolated from crop rhizospheric soils of Southwest Saurashtra Gujarat
Halophiles are one of the classes of extremophilic microorganisms that can flourish in environments with very high salt concentrations. In this study, fifteen bacterial strains isolated from various crop rhizo...
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Open AccessHierarchically porous and single Zn atom-embedded carbon molecular sieves for H2 separations
Hierarchically porous materials containing sub-nm ultramicropores with molecular sieving abilities and microcavities with high gas diffusivity may realize energy-efficient membranes for gas separations. Howeve...
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Open AccessGenetic diversity of 1,845 rhesus macaques improves genetic variation interpretation and identifies disease models
Understanding and treating human diseases require valid animal models. Leveraging the genetic diversity in rhesus macaque populations across eight primate centers in the United States, we conduct targeted-sequ...
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Open AccessA data science roadmap for open science organizations engaged in early-stage drug discovery
The Structural Genomics Consortium is an international open science research organization with a focus on accelerating early-stage drug discovery, namely hit discovery and optimization. We, as many others, bel...
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Open AccessGlobal biogeographic regions for ants have complex relationships with those for plants and tetrapods
On a global scale, biodiversity is geographically structured into regions of biotic similarity. Delineating these regions has been mostly targeted for tetrapods and plants, but those for hyperdiverse groups su...
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Open AccessLate Paleocene paleoclimate recorded in fluid inclusion of halite in Subei basin, East China
Salt deposits are indicative of relatively extreme climate events. However, due to insufficient independent temperature proxies, paleotemperature records obtained from salt deposition are still lack. The Paleo...
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Open AccessSHP2 as a primordial epigenetic enzyme expunges histone H3 pTyr-54 to amend androgen receptor homeostasis
Mutations that decrease or increase the activity of the tyrosine phosphatase, SHP2 (encoded by PTPN11), promotes developmental disorders and several malignancies by varying phosphatase activity. We uncovered that...
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Open AccessRenal autocrine neuropeptide FF (NPFF) signaling regulates blood pressure
The kidney and brain play critical roles in the regulation of blood pressure. Neuropeptide FF (NPFF), originally isolated from the bovine brain, has been suggested to contribute to the pathogenesis of hyperten...
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Open AccessReversible two-way tuning of thermal conductivity in an end-linked star-shaped thermoset
Polymeric thermal switches that can reversibly tune and significantly enhance their thermal conductivities are desirable for diverse applications in electronics, aerospace, automotives, and medicine; however, ...
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Open AccessHuman degradation of tropical moist forests is greater than previously estimated
Tropical forest degradation from selective logging, fire and edge effects is a major driver of carbon and biodiversity loss1–3, with annual rates comparable to those of deforestation4. However, its actual extent ...
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Open AccessSirenian genomes illuminate the evolution of fully aquatic species within the mammalian superorder afrotheria
Sirenians of the superorder Afrotheria were the first mammals to transition from land to water and are the only herbivorous marine mammals. Here, we generated a chromosome-level dugong (Dugong dugon) genome. A co...
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Open AccessLight-driven C–H activation mediated by 2D transition metal dichalcogenides
C–H bond activation enables the facile synthesis of new chemicals. While C–H activation in short-chain alkanes has been widely investigated, it remains largely unexplored for long-chain organic molecules. Here...
