85 Result(s)

Article

PBX/Knotted 1 homeobox-2 (PKNOX2) is a novel regulator of myocardial fibrosis

Much effort has been made to uncover the cellular heterogeneities of human hearts by single-nucleus RNA sequencing. However, the cardiac transcriptional regulation networks have not been systematically describ...

Liang Chen, Haotong Li, **aorui Liu… in Signal Transduction and Targeted Therapy (2024)

Article

Validation of the transplant conditioning intensity (TCI) index for allogeneic hematopoietic cell transplantation

The intensity of the conditioning regimen given before allogeneic hematopoietic cell transplantation (allo-HCT) can vary substantially. To confirm the ability of the recently developed transplant conditioning ...

Alexandros Spyridonidis, Myriam Labopin, Tobias Gedde-Dahl… in Bone Marrow Transplantation (2024)

Article

Transcriptomic analysis identifies B-lymphocyte kinase as a therapeutic target for desmoplastic small round cell tumor cancer stem cell-like cells

Desmoplastic small round cell tumor (DSRCT) is an aggressive pediatric cancer caused by the EWSR1-WT1 fusion oncoprotein. The tumor is refractory to treatment with a 5-year survival rate of only 15–25%, necess...

Justin W. Magrath, Dane A. Flinchum, Alifiani B. Hartono… in Oncogenesis (2024)

Article

Cellular zinc metabolism and zinc signaling: from biological functions to diseases and therapeutic targets

Zinc metabolism at the cellular level is critical for many biological processes in the body. A key observation is the disruption of cellular homeostasis, often coinciding with disease progression. As an essent...

Bonan Chen, Peiyao Yu, Wai Nok Chan, Fuda **e… in Signal Transduction and Targeted Therapy (2024)

Article

Correction: MiR-16 mediates trastuzumab and lapatinib response in ErbB-2-positive breast and gastric cancer via its novel targets CCNJ and FUBP1

L. Venturutti, R. I. Cordo Russo, M. A. Rivas, M. F. Mercogliano, F. Izzo… in Oncogene (2023)

Article

VEGF-B prevents excessive angiogenesis by inhibiting FGF2/FGFR1 pathway

Although VEGF-B was discovered as a VEGF-A homolog a long time ago, the angiogenic effect of VEGF-B remains poorly understood with limited and diverse findings from different groups. Notwithstanding, drugs tha...

Chunsik Lee, Rongyuan Chen, Guangli Sun… in Signal Transduction and Targeted Therapy (2023)

Article

WDR5 facilitates recruitment of N-MYC to conserved WDR5 gene targets in neuroblastoma cell lines

Collectively, the MYC family of oncoprotein transcription factors is overexpressed in more than half of all malignancies. The ability of MYC proteins to access chromatin is fundamental to their role in promoti...

Leigh A. Bumpous, Kylie C. Moe, **g Wang, Logan A. Carver… in Oncogenesis (2023)

Article

Monitoring for virus-specific T-cell responses and viremia in allogeneic HSCT recipients: a survey from the EBMT Cellular Therapy & Immunobiology Working Party

Raffaella Greco, Jorinde D. Hoogenboom… in Bone Marrow Transplantation (2023)

Article

Tumor heterogeneity in VHL drives metastasis in clear cell renal cell carcinoma

Loss of function of the von Hippel-Lindau (VHL) tumor suppressor gene is a hallmark of clear cell renal cell carcinoma (ccRCC). The importance of heterogeneity in the loss of this tumor suppressor has been und...

Junhui Hu, ** Tan, Moe Ishihara… in Signal Transduction and Targeted Therapy (2023)

Article

SARS-CoV-2 spike protein induces IL-18-mediated cardiopulmonary inflammation via reduced mitophagy

Cardiopulmonary complications are major drivers of mortality caused by the SARS-CoV-2 virus. Interleukin-18, an inflammasome-induced cytokine, has emerged as a novel mediator of cardiopulmonary pathologies but...

Shuxin Liang, Changlei Bao, Zi Yang, Shiyun Liu… in Signal Transduction and Targeted Therapy (2023)

Article

Breast cancer and neurotransmitters: emerging insights on mechanisms and therapeutic directions

Exploring the relationship between various neurotransmitters and breast cancer cell growth has revealed their likely centrality to improving breast cancer treatment. Neurotransmitters play a key role in breast...

Priya Jayachandran, Francesca Battaglin, Carly Strelez, Annika Lenz… in Oncogene (2023)

Article

Stem cell-based therapy for human diseases

Recent advancements in stem cell technology open a new door for patients suffering from diseases and disorders that have yet to be treated. Stem cell-based therapy, including human pluripotent stem cells (hPSC...

Duc M. Hoang, Phuong T. Pham, Trung Q. Bach… in Signal Transduction and Targeted Therapy (2022)

Article

SFRP2 induces a mesenchymal subtype transition by suppression of SOX2 in glioblastoma

Intratumoral heterogeneity is a characteristic of glioblastomas that contain an intermixture of cell populations displaying different glioblastoma subtype gene expression signatures. Proportions of these popul...

Min Guo, Kaveh M. Goudarzi, Shiva Abedi, Melanie Pieber, Elin Sjöberg… in Oncogene (2021)

Article

No difference in survival after HLA mismatched versus HLA matched allogeneic stem cell transplantation in Ewing sarcoma patients with advanced disease

Patients with advanced Ewing sarcoma (AES) carry a poor prognosis. Retrospectively, we analyzed 66 AES patients treated with allogeneic stem cell transplantation (allo-SCT) receiving HLA-mismatched (group A, n = ...

U. Thiel, S. J. Schober, A. Ranft, H. Gassmann, S. Jabar… in Bone Marrow Transplantation (2021)

Article

Nucleoside reverse transcriptase inhibitors and Kamuvudines inhibit amyloid-β induced retinal pigmented epithelium degeneration

Nonfibrillar amyloid-β oligomers (AβOs) are a major component of drusen, the sub-retinal pigmented epithelium (RPE) extracellular deposits characteristic of age-related macular degeneration (AMD), a common cau...

Siddharth Narendran, Felipe Pereira… in Signal Transduction and Targeted Therapy (2021)

Article

Cancer-associated fibroblast secretion of PDGFC promotes gastrointestinal stromal tumor growth and metastasis

Targeted therapies for gastrointestinal stromal tumor (GIST) are modestly effective, but GIST cannot be cured with single agent tyrosine kinase inhibitors. In this study, we sought to identify new therapeutic ...

Hyunho Yoon, Chih-Min Tang, Sudeep Banerjee, Mayra Yebra, Sangkyu Noh… in Oncogene (2021)

Article

Nerve fibers in the tumor microenvironment in neurotropic cancer—pancreatic cancer and cholangiocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) and cholangiocarcinoma (CCA) are both deadly cancers and they share many biological features besides their close anatomical location. One of the main histological featur...

**uxiang Tan, Shivan Sivakumar, Jan Bednarsch, Georg Wiltberger… in Oncogene (2021)

Article

Comparative analysis of the AIB1 interactome in breast cancer reveals MTA2 as a repressive partner which silences E-Cadherin to promote EMT and associates with a pro-metastatic phenotype

Steroid regulated cancer cells use nuclear receptors and associated regulatory proteins to orchestrate transcriptional networks to drive disease progression. In primary breast cancer, the coactivator AIB1 prom...

Damir Varešlija, Elspeth Ward, Siobhan P. Purcell, Nicola S. Cosgrove… in Oncogene (2021)

Article

RETRACTED ARTICLE: PI3K/Akt pathway and Nanog maintain cancer stem cells in sarcomas

The self-renewal transcription factor Nanog and the phosphoinositide 3-kinase (PI3K)–Akt pathway are known to be essential for maintenance of mesenchymal stem cells. We evaluated their contribution to the main...

Changhwan Yoon, Jun Lu, Brendan C. Yi, Kevin K. Chang, M. Celeste Simon… in Oncogenesis (2021)

Article

FGF18–FGFR2 signaling triggers the activation of c-Jun–YAP1 axis to promote carcinogenesis in a subgroup of gastric cancer patients and indicates translational potential

Fibroblast growth factor receptor type 2 (FGFR2) has emerged as a key oncogenic factor that regulates gastric cancer (GC) progression, but the underlying mechanism of FGF–FGFR2 signaling pathway remains largel...

**glin Zhang, Chi Chun Wong, Kam Tong Leung, Feng Wu, Yuhang Zhou… in Oncogene (2020)