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Open AccessChallenges and visions for managing pain-related insomnia in primary care using the hybrid CBT approach: a small-scale qualitative interview study with GPs, nurses, and practice managers
Chronic pain and insomnia have a complex, bidirectional relationship – addressing sleep complaints alongside pain may be key to alleviating patient-reported distress and disability. Healthcare professionals ha...
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Article
Open AccessThe feasibility of a randomised control trial to assess physiotherapy against surgery for recurrent patellar instability
Patellar instability is a relatively common condition that leads to disability and restriction of activities. People with recurrent instability may be given the option of physiotherapy or surgery though this i...
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Article
Patent ductus arteriosus in preterm infants: is early transcatheter closure a paradigm shift?
The optimal management approach of the patent ductus arteriosus (PDA) in premature infants remains uncertain owing the lack of evidence for long-term benefits and the limited analyses of the complications of m...
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Article
Open AccessRational and design of an individual participant data meta-analysis of spinal manipulative therapy for chronic low back pain—a protocol
Chronic low back pain (LBP) is the leading cause of pain and disability, resulting in a major socioeconomic impact. The Cochrane Review which examined the effect of spinal manipulative therapy (SMT) for chroni...
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Article
Open AccessBehavioural interventions for people living with adult-onset primary dystonia: a systematic review
Primary dystonia is a chronic neurological movement disorder that causes abnormal muscle movements. Pain and emotional distress may accompany these physical symptoms. Behavioural interventions are used to help...
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Article
Multimode optomechanical dynamics in a cavity with avoided crossings
Cavity optomechanics offers powerful methods for controlling optical fields and mechanical motion. A number of proposals have predicted that this control can be extended considerably in devices where multiple ...
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Article
Open AccessPK/PD modeling supports the dose-escalation decision in VIKING
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Open AccessNovel monitoring technique to minimise the risk for patients participating in pilot studies of investigational compounds
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A randomized control trial comparing adaptive support ventilation with pressure-regulated volume control ventilation in weaning patients after cardiac surgery
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Article
Open AccessIdentification of potential diagnostic markers of prostate cancer and prostatic intraepithelial neoplasia using cDNA microarray
The identification of novel genes or groups of genes expressed in prostate cancer may allow earlier diagnosis or more accurate staging of the disease. We describe the assembly and use of a 1877-member microarr...
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Article
Open AccessImproving the outcome of salvage treatment for non-seminomatous germ cell tumours (NSGCT)
Between 1991–96, 41 patients were treated in this unit for relapsed non-seminomatous germ cell tumours (NSGCT). Twenty-eight patients had raised markers at relapse: 17 required salvage chemotherapy and post-ch...
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Article
Tissue Residues in Male Chickens Fed a 50 ng/kg Dietary Concentration of 2,3,7,8-Tetrachlorodibenzo-p-dioxin
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Article
Adductor pollicis. The missing interosseous
This paper highlights the many similarities between the adductor pollicis and the palmar interossei. In particular it compares their anatomy, innervation and function. It suggests that adductor pollicis should...