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    Detailed computational study of p53 and p16: using evolutionary sequence analysis and disease-associated mutations to predict the functional consequences of allelic variants

    Deciding whether a missense allelic variant affects protein function is important in many contexts. We previously demonstrated that a detailed analysis of p53 intragenic conservation correlates with somatic mutat...

    M S Greenblatt, J G Beaudet, J R Gump, K S Godin, L Trombley, J Koh, J P Bond in Oncogene (2003)