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  1. Article

    Open Access

    Therapeutic targeting of CK2 in acute and chronic leukemias

    CK2 is a ubiquitously expressed, constitutively active Ser/Thr protein kinase, which is considered the most pleiotropic protein kinase in the human kinome. Such a pleiotropy explains the involvement of CK2 in ...

    F Buontempo, J A McCubrey, E Orsini, M Ruzzene, A Cappellini, A Lonetti… in Leukemia (2018)

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  2. No Access

    Article

    Protein kinase CK2 in hematologic malignancies: reliance on a pivotal cell survival regulator by oncogenic signaling pathways

    CK2 is a multitask kinase whose role is essential for a countless number of cellular processes, many of which are critical for blood cell development. A prevailing task for this kinase rests on counteracting p...

    F Piazza, S Manni, M Ruzzene, L A Pinna, C Gurrieri, G Semenzato in Leukemia (2012)

  3. No Access

    Chapter

    Vibroacoustic Energy Diffusion Optimization in Beams and Plates by Means of Distributed Shunted Piezoelectric Patches

    This chapter proposes a synthesis of different new methodologies for develo** a distributed, integrated shunted piezo composite for beams and plates applications able to modify the structural vibro acoustica...

    M. Collet, M. Ouisse, K. A. Cunefare… in Vibration and Structural Acoustics Analysis (2011)

  4. No Access

    Chapter and Conference Paper

    Analytical and Experimental Analysis of Bandgaps in Nonlinear one Dimensional Periodic Structures

    Wave propagation characteristics of nonlinear one-dimensional periodic structures are investigated analytically, numerically and experimentally. A novel perturbation analysis is first applied to predict the ba...

    Nicholas Boechler, Chiara Daraio… in IUTAM Symposium on Recent Advances of Acou… (2010)

  5. No Access

    Article

    Pharmacological inhibition of protein kinase CK2 reverts the multidrug resistance phenotype of a CEM cell line characterized by high CK2 level

    Protein kinase CK2 is an ubiquitous and constitutively active kinase, which phosphorylates many cellular proteins and is implicated in the regulation of cell survival, proliferation and transformation. We inve...

    G Di Maira, F Brustolon, J Bertacchini, K Tosoni, S Marmiroli, L A Pinna… in Oncogene (2007)

  6. No Access

    Article

    Phosphorylation and activation of the atypical kinase p53-related protein kinase (PRPK) by Akt/PKB

    p53-related protein kinase (PRPK), the human homologue of yeast Bud32, belonging to a small subfamily of atypical protein kinases, is inactive unless it is previously incubated with cell lysates. Here we show ...

    S. Facchin, M. Ruzzene, C. Peggion, G. Sartori… in Cellular and Molecular Life Sciences (2007)

  7. Article

    Protein kinase CK2 phosphorylates and upregulates Akt/PKB

    Treatment of Jurkat cells with specific inhibitors of protein kinase CK2 induces apoptosis. Here we provide evidence that the antiapoptotic effect of CK2 can be at least partially mediated by upregulation of t...

    G Di Maira, M Salvi, G Arrigoni, O Marin, S Sarno… in Cell Death & Differentiation (2005)

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  8. No Access

    Article

    Optimal design of underwater stiffened shells

    The optimal design parameters of stiffened shells are determined using a rational multicriteria optimization approach. The adopted approach aims at simultaneously minimizing the shell vibration, associated sou...

    W. Akl, M. Ruzzene, A. Baz in Structural and Multidisciplinary Optimization (2002)

  9. No Access

    Chapter and Conference Paper

    Polylysine Activates a Splenic Tyrosine Protein Kinase Encoded by the fgr Protooncogene

    A tyrosine protein kinase previously isolated from rat spleen, conventionally termed TPK-III, displaying autophosphorylation activity [Brunati and Pinna, 1988], has been purified to homogeneity. The enzyme is ...

    A. Donella-Deana, A. M. Brunati, M. Ruzzene… in Tyrosine Phosphorylation/Dephosphorylation… (1993)