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Article
Open AccessReduced preoperative serum choline esterase levels and fecal peritoneal contamination as potential predictors for the leakage of intestinal sutures after source control in secondary peritonitis
The high rate of stoma placement during emergency laparotomy for secondary peritonitis is a paradigm in need of change in the current fast-track surgical setting. Despite growing evidence for the feasibility o...
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Article
Open AccessIn-vitro model to mimic T cell subset change in human PDAC organoid co-culture
Immunotherapies have largely failed as treatment options for pancreatic ductal adenocarcinoma (PDAC). In this field, clinical translational studies into personalized treatment are of fundamental importance. In...
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Article
Aktuelle WSES-AAST-Leitlinie zu anorektalen Notfällen – Zusammenfassung und Kommentar
Die World Society of Emergency Surgery (WSES) und die American Association for the Surgery of Trauma (AAST) haben 2019 im Rahmen der WSES-AAST-Konsensuskonferenz in Parma, Italien die Erstauflage der Leitlinie...
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Article
Open AccessA prospective, randomized assessment of a novel, local antibiotic releasing platform for the prevention of superficial and deep surgical site infections
Despite significant advances in infection control guidelines and practices, surgical site infections (SSIs) remain a substantial cause of morbidity, prolonged hospitalization, and mortality among patients havi...
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Article
Open AccessSarcopenia of kidney transplant recipients as a predictive marker for reduced graft function and graft survival after kidney transplantation
The association between sarcopenia of kidney transplant recipients and outcome after kidney transplantation (KT) has not yet been fully understood and is still considered controversial. The aim of our study wa...
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Thoracic Emergencies
Patients with lung cancer are threatened by a broad spectrum of emergencies ranging from long-term complications like vena cava superior syndrome to acute life-threatening complications like dramatic bleeding ...
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Article
Open AccessSpatiotemporal dynamics of self-organized branching in pancreas-derived organoids
The development dynamics and self-organization of glandular branched epithelia is of utmost importance for our understanding of diverse processes ranging from normal tissue growth to the growth of cancerous ti...
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Article
Open AccessWhen to operate after SARS-CoV-2 infection? A review on the recent consensus recommendation of the DGC/BDC and the DGAI/BDA
Since the eruption of the worldwide SARS-CoV-2 pandemic in late 2019/early 2020, multiple elective surgical interventions were postponed. Through pandemic measures, elective operation capacities were reduced i...
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Article
Open AccessTrans-hiatal herniation following esophagectomy or gastrectomy: retrospective single-center experiences with a potential surgical emergency
Trans-hiatal herniation after esophago-gastric surgery is a potentially severe complication due to the risk of bowel incarceration and cardiac or respiratory complaints. However, measures for prevention and tr...
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Article
Neue WSES-AAST-Leitlinie zum Trauma des Urogenitaltraktes – Zusammenfassung und Kommentar
In Bezug auf die Behandlung von Traumapatienten mit Verletzungen des Urogenitaltraktes bestehen unter den verschiedenen Fachdisziplinen unterschiedliche Ansichten. Die in diesem Beitrag zusammengefasste multid...
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Article
Zusammenfassung und Kommentar zur WSES-Leitlinie Abdomen apertum bei Trauma- und Nichttraumapatienten
Ende 2018 erschien die Erstauflage einer Leitlinie der World Society of Emergency Surgeons (WSES) zur Indikation und Behandlung des offenen Abdomens sowohl bei traumatischen als auch nichttraumatischen Patient...
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Article
Open AccessMorgagni−Larrey diaphragmatic hernia repair in adult patients: a retrospective single-center experience
Morgagni−Larrey congenital diaphragmatic hernia (MLH) is rare in adult patients and surgery is performed infrequently. The evidence regarding the most beneficial treatment modality is low. Nevertheless, with i...
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Article
Neue WSES-AAST-Leitlinie zum Trauma des Duodenums, des Pankreas und der extrahepatischen Gallengänge – Zusammenfassung und Kommentar
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Article
Wearables zum kontextgesteuerten Assessment in der Psychiatrie
Die atemberaubende technologische Entwicklung im Bereich des mobilen Computings, der Smartphones und Wearables eröffnet für die psychiatrische Forschung und Therapie neue Möglichkeiten. Wearables erlauben nich...
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Article
Intra-abdominal sepsis: new definitions and current clinical standards
The abdomen is the second most common source of sepsis and is associated with unacceptably high morbidity and mortality. Recently, the essential definitions of sepsis and septic shock were updated (Third Inter...
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Article
Open AccessTowards apparent convergence in asymptotically safe quantum gravity
The asymptotic safety scenario in gravity is accessed within the systematic vertex expansion scheme for functional renormalisation group flows put forward in Christiansen et al. (Phys Lett B 728:114, 2014), Chris...
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Article
Dreidimensionale Analyse nasaler Physiologie
Die menschliche Nase übernimmt einen großen Teil der Präkonditionierung eingeatmeter Luft. Zahlreiche pathologische Veränderungen können die Physiologie der Nase beeinträchtigen. Die Anfänge der Strömungsanaly...
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Article
HDAC1 and HDAC2 integrate the expression of p53 mutants in pancreatic cancer
Mutation of p53 is a frequent genetic lesion in pancreatic cancer being an unmet clinical challenge. Mutants of p53 have lost the tumour-suppressive functions of wild type p53. In addition, p53 mutants exert t...
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Article
Diagnostische Genauigkeit ambulanter Polygraphiegeräte
Die stationäre Polysomnographie (PSG) gilt als Referenzmethode in der Diagnostik des obstruktiven Schlafapnoesyndroms (OSAS). Aufgrund der Wartezeiten und der Kosten fordern Kostenträger eine ambulante Polygra...
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Article
KrasG12D induces EGFR-MYC cross signaling in murine primary pancreatic ductal epithelial cells
Epidermal growth factor receptor (EGFR) signaling has a critical role in oncogenic Kras-driven pancreatic carcinogenesis. However, the downstream targets of this signaling network are largely unknown. We devel...
