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Article
Erratum: Genetic risk prediction and neurobiological understanding of alcoholism
Correction to: Translational Psychiatry (2014) 4, e391; doi:10.1038/tp.2014.29; published online 20 May 2014 Following publication of the above article, the authors noticed that the twelfth author’s name was m...
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Article
Open AccessGenetic risk prediction and neurobiological understanding of alcoholism
We have used a translational Convergent Functional Genomics (CFG) approach to discover genes involved in alcoholism, by gene-level integration of genome-wide association study (GWAS) data from a German alcohol...
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Article
Open AccessGenome-wide association of mood-incongruent psychotic bipolar disorder
Mood-incongruent psychotic features (MICP) are familial symptoms of bipolar disorder (BP) that also occur in schizophrenia (SZ), and may represent manifestations of shared etiology between the major psychoses....
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Article
A genome-wide association study of attempted suicide
The heritable component to attempted and completed suicide is partly related to psychiatric disorders and also partly independent of them. Although attempted suicide linkage regions have been identified on 2p1...
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Article
TMEM132D, a new candidate for anxiety phenotypes: evidence from human and mouse studies
The lifetime prevalence of panic disorder (PD) is up to 4% worldwide and there is substantial evidence that genetic factors contribute to the development of PD. Single-nucleotide polymorphisms (SNPs) in TMEM13...
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Article
Association between COMT (Val158Met) functional polymorphism and early onset in patients with major depressive disorder in a European multicenter genetic association study
The available data from preclinical and pharmacological studies on the role of the C-O-methyl transferase (COMT) support the hypothesis that abnormal catecholamine transmission has been implicated in the patho...
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Article
Linkage disequilibrium map** at DAT1, DRD5 and DBH narrows the search for ADHD susceptibility alleles at these loci
Abnormalities in dopaminergic neurotransmission are now accepted as factors in predisposing to ADHD. Evidence of associations between dopamine transporter gene polymorphism and ADHD was first reported by Cook et ...
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Chapter and Conference Paper
Neuere Ergebnisse molekulargenetischer Untersuchungen bei psychotischen Erkrankungen
Der erste Schritt zur Aufklärung genetisch (mit) bedingter Erkrankungen besteht in der Lokalisation ätiologisch relevanter Gene im Genom. Bei genetisch komplexen Erkrankungen, wie z. B. den Psychosen, kann nur...
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Chapter and Conference Paper
Genetische Varianten des Dopamin D3-Rezeptors — keine Assoziation mit schizophrenen Erkrankungen
Aus genetischer Sicht gehören die Schizophrenien zu den multifaktoriellen oder genetisch komplexen Erkrankungen. Um einer Aufklärung der genetischen Mechanismen in der Ätiologie näherzukommen, müssen zunächst ...
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Chapter and Conference Paper
Koppelungsuntersuchungen bei bipolar affektiven Psychosen mit hochpolymorphen repetitiven DNA-Sequenzen
Mit Hilfe von Koppelungsuntersuchungen können ätiologisch relevante Gene bei genetisch bedingten Erkrankungen im Genom lokalisiert werden. Bei komplexer oder multifaktorieller Ätiologie, die für die Psychosen ...
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Chapter and Conference Paper
Genetische Hypothesen über psychogeriatrische Erkrankungen
Ätiologie und Pathogenese der meisten psychogeriatrischen Erkrankungen sind heute noch weitgehend unklar. Vielfach lassen sich jedoch post mortem verschiedene neuropathologische und biochemische Veränderungen ...
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Chapter and Conference Paper
Keine Assoziation von Allelen am Tyrosinhydroxylase-Genort mit affektiven Psychosen
Das Enzym Tyrosinhydroxylase (TH) katalysiert den geschwindigkeitsbestimmenden Schritt in der Katecholamin-Biosynthese. Pharmakologische und biochemische Befunde deuten auf einen Beitrag katecholaminerger Mech...