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  1. No Access

    Article

    Systematic mutation screening and association study of the A1 and A2a adenosine receptor genes in panic disorder suggest a contribution of the A2a gene to the development of disease

    Several lines of evidence suggest a contribution of adenosinergic neurotransmission to the development of panic disorder. We therefore hypothesized that variation in the A1 and A2a adenosine receptor (AR) genes m...

    J Deckert, M M Nöthen, P Franke, C Delmo, J Fritze, M Knapp… in Molecular Psychiatry (1998)

  2. No Access

    Article

    Association between hSKCa3 and schizophrenia not confirmed by transmission disequilibrium test in 193 offspring/parents trios

    A possible association between the small conductance calcium-regulated potassium channel gene, hSKCa3, and schizophrenia has recently been described by Chandy et al1 using a case-control design with patients with...

    O Wittekindt, S G Schwab, E Burgert, M Knapp, M Albus, B Lerer… in Molecular Psychiatry (1999)

  3. No Access

    Article

    Serotonin transporter gene and schizophrenia: evidence for association/linkage disequilibrium in families with affected siblings

    The serotonergic (5-HT) system has been implicated in the etiopathogenesis of psychoses. Since the 5-HT transporter plays an important role in regulation of 5-HT transmission, its gene can be considered as a c...

    D Hranilovic, S G Schwab, B Jernej, M Knapp, B Lerer, M Albus… in Molecular Psychiatry (2000)

  4. No Access

    Article

    DRD4 exon III VNTR polymorphism—susceptibility factor for heroin dependence? Results of a case-control and a family-based association approach

    Dopaminergic abnormalities are implicated in the pathogenesis of substance abuse.1 Recently, two reports have been published suggesting an association between opioid dependence and presence of long alleles of the...

    P Franke, M M Nöthen, T Wang, M Knapp, D Lichtermann, H Neidt… in Molecular Psychiatry (2000)

  5. No Access

    Article

    Systematic screening for DNA sequence variation in the coding region of the human dopamine transporter gene (DAT1)

    The dopamine transporter (DAT) plays a central role in dopaminergic neurotransmission in the human brain. Genetic association studies have used a variable number of tandem repeat (VNTR) polymorphism in the 3′-...

    F Grünhage, T G Schulze, D J Müller, M Lanczik, E Franzek, M Albus… in Molecular Psychiatry (2000)

  6. No Access

    Article

    Association study of the low-activity allele of catechol-O-methyltransferase and alcoholism using a family-based approach

    Catechol-O-methyltransferase (COMT) is a major component of the metabolic pathways of neurotransmitters such as dopamine, adrenaline, and noradrenaline. The activity of COMT is known to vary within the populat...

    T Wang, P Franke, H Neidt, S Cichon, M Knapp, D Lichtermann… in Molecular Psychiatry (2001)

  7. No Access

    Article

    Evidence for association of DNA sequence variants in the phosphatidylinositol-4-phosphate 5-kinase IIα gene (PIP5K2A) with schizophrenia

    Linkage studies in schizophrenia have identified a candidate region on chromosome 10p14–11 as reported for several independent samples. We investigated association of DNA sequence variants in a plausible candi...

    S G Schwab, M Knapp, P Sklar, G N Eckstein, C Sewekow… in Molecular Psychiatry (2006)