18 Result(s)
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Article
Open AccessRepeated exposure to systemic inflammation and risk of new depressive symptoms among older adults
Evidence on systemic inflammation as a risk factor for future depression is inconsistent, possibly due to a lack of regard for persistency of exposure. We examined whether being inflamed on multiple occasions ...
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Open AccessHealthy obesity and risk of accelerated functional decline and disability
Some obese adults have a normal metabolic profile and are considered ‘healthy’, but whether they experience faster ageing than healthy normal-weight adults is unknown. We compared decline in physical function,...
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Open AccessBody mass index as a predictor of healthy and disease-free life expectancy between ages 50 and 75: a multicohort study
While many studies have shown associations between obesity and increased risk of morbidity and mortality, little comparable information is available on how body mass index (BMI) impacts health expectancy. We e...
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Depressive symptoms and obesity: instrumental variable analysis using mother–offspring pairs in the 1970 British Cohort Study
The extent to which depression and obesity are causally related remains to be determined. We used intergenerational data on mother–offspring pairs in an instrumental variable analysis to examine the longitudin...
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Open AccessInsulin-like growth factor 1 and risk of depression in older people: the English Longitudinal Study of Ageing
Depressive disorders are a leading cause of disability in older age. Although the role of psychosocial and behavioural predictors has been well examined, little is known about the biological origins of depress...
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Healthy obesity is not safe obesity
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Open AccessSarcopenic obesity and risk of new onset depressive symptoms in older adults: English Longitudinal Study of Ageing
We examined the role of sarcopenic obesity as a risk factor for new-onset depressive symptoms over 6-year follow-up in a large sample of older adults.
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Article
Open AccessJob strain and risk of obesity: systematic review and meta-analysis of cohort studies
Job strain, the most widely used indicator of work stress, is a risk factor for obesity-related disorders such as cardiovascular disease and type 2 diabetes. However, the extent to which job strain is related ...
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Association of metabolically healthy obesity with depressive symptoms: pooled analysis of eight studies
The hypothesis of metabolically healthy obesity posits that adverse health effects of obesity are largely avoided when obesity is accompanied by a favorable metabolic profile. We tested this hypothesis with de...
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Article
Conflicts Between Work and Family Life and Subsequent Sleep Problems Among Employees from Finland, Britain, and Japan
Research on the association between family-to-work and work-to-family conflicts and sleep problems is sparse and mostly cross-sectional. We examined these associations prospectively in three occupational cohorts.
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Open AccessLong-term inflammation increases risk of common mental disorder: a cohort study
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Article
Evaluation of common genetic variants identified by GWAS for early onset and morbid obesity in population-based samples
Meta-analysis of case–control genome-wide association studies (GWAS) for early onset and morbid obesity identified four variants in/near the PRL, PTER, MAF and NPC1 genes.
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Article
Risk of future depression in people who are obese but metabolically healthy: the English longitudinal study of ageing
There is some evidence to suggest that obesity is a risk factor for the development of depression, although this is not a universal finding. This discordance might be ascribed to the existence of a ‘healthy ob...
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Article
Bidirectional association between depression and obesity in middle-aged and older women
Although it has been hypothesized that the depression–obesity relation is bidirectional, few studies have addressed this hypothesis in a prospective setting. We aimed to examine the bidirectional relationship ...
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Article
Open AccessHostility in adolescents and adults: a genome-wide association study of the Young Finns
Hostility is a multidimensional personality trait with changing expression over the life course. We performed a genome-wide association study (GWAS) of the components of hostility in a population-based sample ...
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Article
Open AccessP9.01 Determinants of Arterial Stiffness: A 16-Year Follow-Up from the Whitehall Ii Study
Although several risk factors for cardiovascular disease (CVD) have been shown to be associated with arterial stiffness, the relative importance of these determinants is largely unknown. The aim of this study ...
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Obesity and overweight in relation to liver disease mortality in men: 38 year follow-up of the original Whitehall study
Obesity has been implicated in the aetiology of liver disease. However, to date, evidence is largely drawn from cross-sectional studies, where interpretation is hampered by reverse causality, and from studies ...
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Work stress, weight gain and weight loss: evidence for bidirectional effects of job strain on body mass index in the Whitehall II study
Previous research has focused on overall associations between work stress and body mass index (BMI) ignoring the possibility that stress may cause some people to eat less and lose weight and others to eat more...
