-
Article
Scrapie inoculation of mice: light and electron microscopy of the superior colliculi
Ultrastructural examination of the superior colliculi of mice intraocularly inoculated with the ME7 strain of scrapie showed vacuolation early in the course of infection. Brains were examined between 85–260 da...
-
Article
Ultrastructural features of spongiform encephalopathy transmitted to mice from three species of bovidae
The ultrastructural neuropathology of mice experimentally inoculated with brain tissue of nyala (Tragelaphus angasi; subfamily Bovinae), or kudu (Tragelaphus strepsiceros; subfamily Bovinae) affected with spongif...
-
Article
A morphometric and immunohistochemical study of the vestibular nuclear complex in bovine spongiform encephalopathy
A morphometric and immunohistochemical study of the vestibular nuclear complex was performed on five bovine spongiform encephalopathy (BSE) and five control cow brains. Neurons of the lateral and superior vest...
-
Article
PrP in pathology and pathogenesis in scrapie-infected mice
PrP accumulation in the brains of mice infected with scrapie takes several different forms: amyloid plaques, widespread accumulation in neuropile, and perineuronal deposits. PrP is also sometimes detected with...
-
Article
Early loss of neurons and axon terminals in scrapie-affected mice revealed by morphometry and immunocytochemistry
This study demonstrates that an unsuspected and dramatic neuronal loss occurs in the dLGN of mice intraocularly infected with ME7 scrapie, up to 100 d before clinical signs are apparent. The onset of detectabl...
-
Article
Tubulovesicular structures are not labeled using antibodies to prion protein (PrP) with the immunogold electron microscopy techniques
Tubulovesicular structures (TVS) are disease-specific, intraneuronal particles found by thin-section electron microscopy in all of the transmissible spongiform encephalopathies. We used immunogold (both 10 nm...
-
Chapter
Electron Microscopy in Prion Research: Tubulovesicular Structures Are Not Composed of Prion Protein (PrP) but They May Be Intimately Associated with PrP Amyloid Fibrils
In a recent monograph on electron microscopy of prion diseases one of us wrote „Attempts, using thin-section transmission electron microscopy, to define the structure of the infectious virus of scrapie (and an...
-
Chapter
Cellular and sub-cellular localisation of PrP in the lymphoreticular system of mice and sheep
Using immunocytochemistry or immunogold electron microscopy, abnormal PrP accumulation was found in lymphoreticular tissues of Suffolk sheep naturally exposed to scrapie and in the spleens of ME7 infected C57 ...
-
Article
Tubulovesicular particles occur early in the incubation period of murine scrapie
Tubulovesicular bodies are structures, apparently specific to the transmissible spongiform encephalopathies, which are of unknown composition and significance. Prion protein (PrP) is absent from tubulovesicul...
-
Chapter
Pathology and Pathogenesis of Bovine Spongiform Encephalopathy and Scrapie
In common with other prion diseases or transmissible spongiform encephalopathies (TSEs), scrapie of sheep and bovine spongiform encephalopathy (BSE) are characterized by grey matter vacuolation and accumulatio...
-
Article
c-Myc activates multiple metabolic networks to generate substrates for cell-cycle entry
Cell proliferation requires the coordinated activity of cytosolic and mitochondrial metabolic pathways to provide ATP and building blocks for DNA, RNA and protein synthesis. Many metabolic pathway genes are ta...
-
Article
Lacrimal sac pigmentation due to mascara
-
Article
Response to Shah et al
-
Article
Integrating geoelectrical and water chemistry studies to explore environmental challenges with an Indigenous community in northern Canada
The FN, an undisclosed Indigenous community in northern Canada, is affected by pollution sources allegedly linked to health issues. Environmental records in The FN's water quality reports are insufficient for ...
