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    Article

    Bfl-1/A1 functions, similar to Mcl-1, as a selective tBid and Bak antagonist

    The prosurvival Bcl-2-family member Bfl-1/A1 is a transcriptional target of nuclear factor-κB (NF-κB) that is overexpressed in many human tumors and is a means by which NF-κB inhibits apoptosis, but its mode o...

    M J Simmons, G Fan, W-X Zong, K Degenhardt, E White, C Gélinas in Oncogene (2008)

  2. Article

    Constitutive proteasome-mediated turnover of Bfl-1/A1 and its processing in response to TNF receptor activation in FL5.12 pro-B cells convert it into a prodeath factor

    Bfl-1/A1 is generally recognized as a Bcl-2-related inhibitor of apoptosis. We show that Bfl-1 undergoes constitutive ubiquitin/proteasome-mediated turnover. Moreover, while Bfl-1 suppresses apoptosis induced ...

    J F Kucharczak, M J Simmons, C S Duckett, C Gélinas in Cell Death & Differentiation (2005)

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    Chapter and Conference Paper

    An Investigation of Active, Suction, Shock and Boundary Layer Control Techniques

    This report describes experimental and theoretical studies at high subsonic speeds on a two-dimensional airfoil of novel drag reduction systems. The control systems are all ‘active’ in the sense that they util...

    J. L. Fulker, M. J. Simmons in Drag Reduction by Shock and Boundary Layer Control (2002)

  4. No Access

    Chapter

    An Experimental Investigation of Passive Shock/Boundary-Layer Control on an Aerofoil

    An experiment at high subsonic speeds on a two-dimensional aerofoil model is described, with a passive system for the control of shock waves via a porous skin and under-surface cavity. Passive control utilises...

    J. L. Fulker, M. J. Simmons in EUROSHOCK - Drag Reduction by Passive Shock Control (1997)