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  1. No Access

    Article

    Genetic variants of kinase suppressors of Ras (KSR1) to predict survival in patients with ERα-positive advanced breast cancer

    In patients with breast cancer (BC), deregulation of estrogen receptor (ERα) activity may account for most resistance to endocrine therapies. Our previous study used a whole-human kinome siRNA screen to identi...

    L Benhaim, W Zhang, T Wakatsuki, D Yang, A Gerger… in The Pharmacogenomics Journal (2015)

  2. No Access

    Article

    Integrin genetic variants and stage-specific tumor recurrence in patients with stage II and III colon cancer

    Integrins (ITGs) are key elements in cancer biology, regulating tumor growth, angiogenesis and lymphangiogenesis through interactions of the tumor cells with the microenvironment. Moving from the hypothesis th...

    P Bohanes, D Yang, F Loupakis, M J LaBonte, A Gerger… in The Pharmacogenomics Journal (2015)

  3. No Access

    Article

    The cyclin D1 (CCND1) rs9344 G>A polymorphism predicts clinical outcome in colon cancer patients treated with adjuvant 5-FU-based chemotherapy

    Recent evidence indicates a potential prognostic and predictive value for germline polymorphisms in genes involved in cell cycle control. We investigated the effect of cyclin D1 (CCND1) rs9344 G>A in stage II/...

    G Absenger, L Benhaim, J Szkandera, W Zhang, D Yang… in The Pharmacogenomics Journal (2014)

  4. No Access

    Article

    Association of common gene variants in the WNT/β-catenin pathway with colon cancer recurrence

    Wnt/β-catenin signaling has a central role in the development and progression of most colon cancers (CCs). Germline variants in Wnt/β-catenin pathway genes may result in altered gene function and/or activity, ...

    D Páez, A Gerger, W Zhang, D Yang, M J Labonte, L Benhanim… in The Pharmacogenomics Journal (2014)

  5. No Access

    Article

    Gender-specific profiling in SCN1A polymorphisms and time-to-recurrence in patients with stage II/III colorectal cancer treated with adjuvant 5-fluoruracil chemotherapy

    This study was designed to analyze the gender-related association between SCN1A polymorphisms (voltage-gated sodium channels; α-subunit) and time-to-recurrence (TTR) in patients with colorectal cancer (CRC) treat...

    L Benhaim, A Gerger, P Bohanes, D Paez, T Wakatsuki, D Yang… in The Pharmacogenomics Journal (2014)

  6. No Access

    Article

    Selecting the best targeted agent in first-line treatment of unresectable liver metastases from colorectal cancer: does the bench have the answers?

    For physicians facing patients with organ-limited metastases from colorectal cancer, tumor shrinkage and sterilization of micrometastatic disease is the main goal, giving the opportunity for secondary surgical...

    L. Benhaim, F. Loupakis, M. J. LaBonte… in Journal of Hepato-Biliary-Pancreatic Scien… (2012)

  7. Article

    Open Access

    Interleukin-8 and its receptor CXCR2 in the tumour microenvironment promote colon cancer growth, progression and metastasis

    Colorectal cancer (CRC) is a leading cause of death in the United States. Increased level of interleukin-8 (IL-8) and CXCR2 on tumours and in the tumour microenvironment has been associated with CRC growth, pr...

    Y S Lee, I Choi, Y Ning, N Y Kim, V Khatchadourian, D Yang… in British Journal of Cancer (2012)

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