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    Synergistic activity and heterogeneous acquired resistance of combined MDM2 and MEK inhibition in KRAS mutant cancers

    There are currently no effective targeted therapies for KRAS mutant cancers. Therapeutic strategies that combine MEK inhibitors with agents that target apoptotic pathways may be a promising therapeutic approach. ...

    A N Hata, S Rowley, H L Archibald, M Gomez-Caraballo, F M Siddiqui, F Ji… in Oncogene (2017)