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Article
Alternative splicing of the ErbB-4 cytoplasmic domain and its regulation by hedgehog signaling identify distinct medulloblastoma subsets
Medulloblastoma (MB) results from aberrant development of cerebellar neurons in which altered hedgehog (Hh) signalling plays a major role. We investigated the possible influence of Hh signalling on ErbB-recept...
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Article
Two-hit model for progression of medulloblastoma preneoplasia in Patched heterozygous mice
Inactivation of one Ptc1 allele predisposes humans and mice to spontaneous medulloblastoma development, and irradiation of newborn Ptc1 heterozygous mice results in dramatic increase of medulloblastoma incidence....
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Article
Open AccessSurvivin expression in ovarian cancer and its correlation with clinico-pathological, surgical and apoptosis-related parameters
We investigated the association of survivin expression with prognosis and other apoptosis-related biological factors in 110 primary ovarian cancer patients admitted to the Division of Gynecologic Oncology, Cat...
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Article
Rosette-forming glioneuronal tumour of the fourth ventricle: report of a case with clinical and surgical implications
A 32-year-old woman presented with a 2-month history of episodic headache, cervical pain and neck rigidity. Neurological examination showed a moderate dysmetria. Magnetic resonance imaging (MRI) revealed a mas...
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Article
Infantile myofibromatosis of the central nervous system
Infantile myofibromatosis is the most common fibrous disorder of infancy and childhood. It may occur in two distinct forms: multicentric and solitary. In both cases involvement of the central nervous system (C...
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Article
Open AccessExpression of cyclooxygenase-2 (COX-2) in tumour and stroma compartments in cervical cancer: clinical implications
This study aims at investigating the relationship between cyclooxygenase-2 expression in tumour vs stroma inflammatory compartment and its possible clinical role. The study included 99 stage IB-IV cervical cancer...
