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Article
Open AccessThe dysfunctional immune response in renal cell carcinoma correlates with changes in the metabolic landscape of ccRCC during disease progression
Renal cell carcinoma is an immunogenic tumour with a prominent dysfunctional immune cell infiltrate, unable to control tumour growth. Although tyrosine kinase inhibitors and immunotherapy have improved the out...
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Article
Reduced-intensity conditioning is effective and safe for transplantation of patients with Shwachman–Diamond syndrome
Allogeneic hematopoietic stem cell transplantation (HSCT) is the only potentially curative treatment for the BM dysfunction seen in patients with Shwachman–Diamond syndrome (SDS). Historically, these patients ...
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Article
Reproduction of ON-center and OFF-center self-rotations
In self-rotation reproduction tasks, subjects appear to estimate the displacement angle and then reproduce this angle without necessarily replicating the entire temporal velocity profile. In contrast, subjects...
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Article
Rat bladder in the early stages of streptozotocin-induced diabetes: adrenergic and cholinergic innervation
The adrenergic and cholinergic innervation of the bladder was studied in streptozotocin-diabetic rats. The presence of hypertrophy and distension in the ‘diabetic’ bladders necessitates care in assessing chang...